Peter Gallant and colleagues show that the control of endoreplication and cell competition in Drosophila are activities of Myc proto-oncogene in vivo that do not require the association with its Max binding partner. Further, a Myc derivative that does not interact with Max retains substantial biological activity, and Myc can control RNA polymerase III independently of Max.
- Dominik Steiger
- Michael Furrer
- Peter Gallant