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Showing 1–7 of 7 results
Advanced filters: Author: Philipp M Altrock Clear advanced filters

  • Authors report that long-term intestinal tissue maintenance in naked mole rats is achieved by having an expanded pool of slow-dividing adult stem cells while a higher proportion of differentiated cells confer enhanced function and protection to the intestinal mucosa.

    • Shamir Montazid
    • Sheila Bandyopadhyay
    • Shazia Irshad
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • This Review discusses mathematical modelling approaches in cancer research. These models can complement experimental and clinical studies, but can also challenge current paradigms, redefine our understanding of mechanisms driving tumorigenesis and shape future research.

    • Philipp M. Altrock
    • Lin L. Liu
    • Franziska Michor
    Reviews
    Nature Reviews Cancer
    Volume: 15, P: 730-745

  • Although tumours evolve in a Darwinian fashion, they do not undergo sexual reproduction. The authors show experimentally and using mathematical modelling that spontaneous fusion between cancer cells allows recombination between clones and the possibility of exploring larger areas of the adaptive landscape.

    • Daria Miroshnychenko
    • Etienne Baratchart
    • Andriy Marusyk
    Research
    Nature Ecology & Evolution
    Volume: 5, P: 379-391

  • To investigate the role of sub-clonal tumour heterogeneity in cancer progression, a mouse xenograft model was used which revealed that tumour growth can be driven by a minor cell subpopulation by a non-cell-autonomous mechanism, although this minor subpopulation can be outcompeted by faster proliferating competitors.

    • Andriy Marusyk
    • Doris P. Tabassum
    • Kornelia Polyak
    Research
    Nature
    Volume: 514, P: 54-58

  • Gregory Kimmel et al. model the population dynamics of public goods games in which interactions occur within local neighborhoods but density dependence is global. They find that neighborhood size drives changes between different evolutionary dynamics and apply their model to dynamics observed in cell populations.

    • Gregory J. Kimmel
    • Philip Gerlee
    • Philipp M. Altrock
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10