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Showing 1–13 of 13 results
Advanced filters: Author: Philippe Mathurin Clear advanced filters

  • Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

    • Luis Antonio Diaz
    • Maja Thiele
    • Rohit Loomba
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    P: 1-19

  • Alcoholic liver disease is characterized by a complex spectrum of histological lesions, ranging from steatosis to cirrhosis. This Review discusses the main pathways associated with the progression of liver disease, as well as potential therapeutic strategies targeting these pathways. The need to adapt the design of future studies to the histological lesions of the disease is also highlighted.

    • Alexandre Louvet
    • Philippe Mathurin
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 231-242

  • Alcoholic hepatitis is characterized by intense liver inflammation driven by excessive cytokines and chemokines production and immune cell infiltration. Here the authors identify a super-enhancer that regulates the expression of multiple CXCL chemokines in alcoholic hepatitis and may be a potential therapeutic target.

    • Mengfei Liu
    • Sheng Cao
    • Vijay H. Shah
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • In patients with alcoholic hepatitis, cytolysin-positive Enterococcus faecalis strains are correlated with liver disease severity and increased mortality, and in mouse models these strains can be specifically targeted by bacteriophages.

    • Yi Duan
    • Cristina Llorente
    • Bernd Schnabl
    Research
    Nature
    Volume: 575, P: 505-511

  • Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation.

    • Julien Bricambert
    • Marie-Clotilde Alves-Guerra
    • Renaud Dentin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.

    • Josepmaria Argemi
    • Maria U. Latasa
    • Ramon Bataller
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Global alcohol consumption has increased in the past two decades and is projected to increase further. In this Review, Loomba and colleagues discuss the global epidemiology of alcohol-associated cirrhosis and hepatocellular carcinoma, including risk factors, trends and projections.

    • Daniel Q. Huang
    • Philippe Mathurin
    • Rohit Loomba
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 37-49

  • Alcoholic liver disease refers to a spectrum of disorders that are caused by chronic alcohol consumption. This Primer covers the epidemiology, mechanisms, diagnosis and management of alcoholic liver disease.

    • Helmut K. Seitz
    • Ramon Bataller
    • Hidekazu Tsukamoto
    Reviews
    Nature Reviews Disease Primers
    Volume: 4, P: 1-22