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Showing 1–9 of 9 results
Advanced filters: Author: Philippe Pibarot Clear advanced filters

  • Patient-prosthesis mismatch (PPM) is common after aortic valve replacement and has been shown to be associated with poor hemodynamic and symptomatic status, a high rate of cardiac events, and increased mortality. In this article, Philippe Pibarot and Jean G. Dumesnil highlight the importance of defining and recognizing PPM and its clinical impact. They also assert that, because PPM is a predictable and modifiable risk factor, it is vital to identify susceptible patients and to apply preventive strategies to avoid PPM or reduce its severity.

    • Philippe Pibarot
    • Jean G Dumesnil
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: 764-765

  • During 2010, several landmark studies, including the PARTNER trial, have made huge advances in the field of transcatheter aortic valve implantation. Other studies have made major contributions to the therapeutic management of young adult patients with severe aortic valve disease and of patients with asymptomatic severe mitral regurgitation.

    • Philippe Pibarot
    News & Views
    Nature Reviews Cardiology
    Volume: 8, P: 75-77

  • Multivalvular disease is common among patients with valvular disease, and has a complex pathophysiology. In this Review, Unger et al. discuss the mechanisms, diagnosis, and percutaneous and surgical treatment of multivalvular disease, focusing on the combinations of valve pathologies that are most often encountered in clinical practice.

    • Philippe Unger
    • Marie-Annick Clavel
    • Philippe Pibarot
    Reviews
    Nature Reviews Cardiology
    Volume: 13, P: 429-440

  • Calcific aortic stenosis (AS) involves fibro-calcific remodelling of the aortic valve that causes restriction of blood flow. Pibarot and colleagues discuss the mechanisms, diagnosis and management of AS and highlight how the introduction of transcatheter-based valve replacement has transformed patient outcomes.

    • Brian R. Lindman
    • Marie-Annick Clavel
    • Philippe Pibarot
    Reviews
    Nature Reviews Disease Primers
    Volume: 2, P: 1-28

  • Here the authors report 20 novel genomic risk loci for calcific aortic valve stenosis, the most common heart valve disorder. Using RNA sequencing in 500 human aortic valves, they prioritize candidate causal genes including TWIST1, a gene involved in endothelial-mesenchymal transition.

    • Sébastien Thériault
    • Zhonglin Li
    • Yohan Bossé
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization.

    • Sébastien Thériault
    • Nathalie Gaudreault
    • Yohan Bossé
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • Christian Dina, Nabila Bouatia-Naji, Xavier Jeunemaitre and colleagues from the Leducq Transatlantic MITRAL Network report the results of a genome-wide association study of nonsyndromic mitral valve prolapse. They identify six susceptibility loci and provide functional evidence implicating LMCD1 and TNS1 as genes influencing mitral valve development.

    • Christian Dina
    • Nabila Bouatia-Naji
    • Xavier Jeunemaitre
    Research
    Nature Genetics
    Volume: 47, P: 1206-1211

  • Calcific aortic valve disease and stenosis have a complex pathogenesis, and no therapies are available that can halt or slow their progression. In this Perspective, Narula and colleagues explore a possible relationship between amyloid deposition, calcification and the development of aortic valve stenosis.

    • Karan Sud
    • Navneet Narula
    • Jagat Narula
    Reviews
    Nature Reviews Cardiology
    Volume: 20, P: 418-428