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Crystal structures of the σ₂ receptor are determined and used to perform a docking screen of nearly 500 million molecules, identifying σ₂-selective ligands and providing insight into the role of σ₂ in neuropathic pain.

Isotopic analysis of basalt clasts returned from the Moon by the Chang’e-5 mission indicates that the rocks were derived from a mantle source that lacked potassium, rare-earth elements and phosphorus.

Single-cell transcriptomics roadmap of human dermal fibroblasts reprogrammed to primed and naive pluripotency reveals a route for the direct reprogramming of somatic cells into induced trophoblast stem cells.

Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and the antigenically related Zika virus (ZIKV). Gao and colleagues designed a ZIKV vaccine that induced sterilizing immunity and fetal protection in mice challenged with ZIKV and did not induce ADE following subsequent DENV infection.

Spinon excitations of a Kagome quantum spin liquid are expected to give rise to a magnetic continuum in Raman spectroscopy. Here, the authors report a magnetic Raman continuum in the Kagome spin liquid candidate Cu₃Zn(OH)₆FBr, in contrast to a sharp magnon Raman peak in the Kagome antiferromagnet EuCu₃(OH)₆Cl₃.

MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.

Mercury is a neurotoxin and pollutant with enhanced emissions from anthropogenic activities. Here, the authors develop a global emissions, transport, and human risk model and find substantial future losses in revenue and public health if emission reductions proposed by the Minamata Convention are delayed.

Voltage control of magnetic order is one of the keys to energy-efficient spintronic applications. Voltage gating using a solid-state hydrogen pump now allows for reversible control of ferrimagnetic order, external-field-free 180° magnetic switching and ferrimagnetic spin texture writing.

How to curb climate change is uncertain, in part because determination of allowable emissions depends on models with low accuracy. Here the authors re-analyze climate-carbon feedbacks and find that CO₂ emissions could be 9 ± 7% higher and still meet Paris Agreement goals.

A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

A simple but flexible technique based on a capillary-force-driven rolling-up process produces high-order van der Waals superlattices that are hard to produce with existing fabrication techniques.

It is hoped that quantum computers may be faster than classical ones at solving optimization problems. Here the authors implement a quantum optimization algorithm over 23 qubits but find more limited performance when an optimization problem structure does not match the underlying hardware.

The periodic domain pattern of BiFeO₃ enables the anisotropic superconductivity in YBa₂Cu₃O_7 − x. In this work, we introduce a design of periodic multiferroic domain patterns to create the anisotropic superconductivity. High T_C can be found when we measured the resistance parallel to the domain wall direction and the broader transition with lower T_C is found to be perpendicular to the domain walls. (a) and (b) the resistance versus temperature in YBa₂Cu₃O_7 − x/BiFeO₃ heterostructures with two different domain patterns 109° and 71°, respectively.

Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability.

Platinum based drugs like cisplatin are common chemotherapy treatments for cancer. Here, the authors report on the in situ formation of platinum nanoparticles in patients and demonstrated how platinum nanoparticles can be synthesized using patients’ blood and provide effective drug delivery and cancer treatments.

The monitoring of nitric oxide is important to a number of disease states and biomedical applications. Here, the authors report on a single nickel atom catalyst based sensor for detecting nitric oxide production from cells.

The off-target effects and on-target mutations of CRISPR editing in higher non-human primates are complex. Here the authors perform whole genome trio sequencing of rhesus monkeys and see no unexpected mutations.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

The supra-amphiphiles spontaneously assemble to well-defined nanostructures but control of shape and size of supramolecular nanostructures is still a great challenge. Here the authors demonstrate control over shape and size of self-assemblies by using the recognition motifs of an amphiphilic porphyrin

Using cryo-electron microscopy, the authors report the structures of G-protein-coupled bile acid receptor–G_s complexes and reveal the structural basis of bile acid recognition.

Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.

Chen et al. show that tumour-associated macrophages transmit HIF-1α-stabilizing long noncoding RNA through extracellular vesicles to breast cancer cells, thereby enhancing tumour glycolysis and chemoresistance.

Sequencing of haploid sugarcane, Saccharum spontaneum, allows assembly of a prototypical version of the sugarcane chromosome set. This new reference genome will serve as a resource to accelerate sugarcane improvement.

Aging is the major risk factor for cardiovascular diseases due to chronic, low-grade inflammation stemmed from pro-inflammatory factors circulating in the body. Here, the authors identify a role of hepatocyte specific peroxisomal import in mediating non-autonomous regulation of cardiac aging, through upregulation of IL6-like inflammatory cytokine.

Quantum supremacy is demonstrated using a programmable superconducting processor known as Sycamore, taking approximately 200 seconds to sample one instance of a quantum circuit a million times, which would take a state-of-the-art supercomputer around ten thousand years to compute.

An integrated one selector–one resistor device is realized using the volatile and non-volatile switching properties of ferroelectric domains created, respectively, at the interface and in the bulk of mesa-like LiNbO₃ domain wall memory cells.

While single-atom catalysis offers an efficient materials usage, the ambiguous interactions with supports poses a difficulty in understanding catalytic performances. Here, authors show an ensemble effect via synergy of Co adatoms and the S of MoS₂ supports to boost hydrogen evolution activities.