Nature Search

Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome

In the context of parental or diet-induced obesity, preweaning ketosis contributes to improved health outcomes, particularly by regulating the histone acetylome and β-hydroxybutyrylome for transcriptional activation of beige fat biogenesis genes.

Chung-Lin Jiang
Pei-Hsiang Lai
Fu-Jung Lin
Research09 Oct 2025
Nature Metabolism

P: 1-22
KLHL23 and RhoGDI coordinate CDC42 inactivation ensuring membrane homeostasis

KLHL23 and RhoGDI compete for CDC42’s switch II region in a GTP- or GDP-dependent manner, driving spatiotemporal inactivation through degradation or sequestration. This dynamic control maintains membrane homeostasis and is impaired in Takenouchi–Kosaki Syndrome.

Po-Cheng Liao
Hao-Chun Chang
Sen-Yung Hsieh
Research22 Aug 2025
Nature Chemical Biology

P: 1-11
Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

T-cell enrichment has attracted great interest but currently fails to fully replicate the complex natural immune interactions. Here, the authors report on magnetic polymerised antigen-presenting cells that mimic natural interactions to isolate rare tumour-reactive T cells, offering a platform for enhancing cancer immunotherapy and neoantigen discovery.

Chung-Yao Hsu
Po-Cheng Tsai
Che-Ming Jack Hu
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-16
In-plane gate graphene transistor with epitaxially grown molybdenum disulfide passivation layers

Po-Cheng Tsai
Chun-Wei Huang
Shih-Yen Lin
ResearchOpen Access06 Jun 2023
Scientific Reports

Volume: 13, P: 1-7
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Effect of noisy galvanic vestibular stimulation on dynamic posture sway under visual deprivation in patients with bilateral vestibular hypofunction

Po-Yin Chen
Ying-Chun Jheng
Chung-Lan Kao
ResearchOpen Access19 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
Carrier dynamics of Mn-induced states in GaN thin films

Yu-Ting Chen
Chi-Yuan Yang
Kung-Hsuan Lin
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Advanced liquid crystal devices for augmented reality and virtual reality displays: principles and applications

Advanced liquid crystal-based light engines and planar optical components play pivotal roles for systematically improving the image quality and formfactor of the augmented reality and virtual reality displays.

Kun Yin
En-Lin Hsiang
Shin-Tson Wu
ReviewsOpen Access30 May 2022
Light: Science & Applications

Volume: 11, P: 1-22

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