Epigenetic modulation of hosts by pathogenic bacteria is underexplored. Here, Yaseen et al. show that protein Rv1988 from Mycobacterium tuberculosisenhances microbial survival by methylating histone H3 in the host cell nucleus and thus altering host gene expression.
- Imtiyaz Yaseen
- Prabhjot Kaur
- Sanjeev Khosla