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Showing 1–9 of 9 results
Advanced filters: Author: Pradeep D. Uchil Clear advanced filters
  • Alfajaro et al identify that a bat MERS-like coronavirus HKU5 uses ACE2 as a receptor from its natural bat reservoir Pipistrellus abramus and American mink. Structural analyses demonstrate a unique interaction between the HKU5 receptor binding domain and bat ACE2. This highlights the receptor flexibility of merbecoviruses and identifies mink as potential intermediate hosts, informing viral surveillance and countermeasure development.

    • Mia Madel Alfajaro
    • Emma L. Keeler
    • Craig B. Wilen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • A study reports that the structural maturation of the matrix domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.

    • James C. V. Stacey
    • Dominik Hrebík
    • John A. G. Briggs
    ResearchOpen Access
    Nature
    Volume: 640, P: 258-264
  • Phospholipid scramblase 1 (PLSCR1), a protein induced by IFNγ, acts as a defence factor against SARS-CoV-2 and other coronaviruses by inhibiting the fusion of the virus with host-cell membranes.

    • Dijin Xu
    • Weiqian Jiang
    • John D. MacMicking
    ResearchOpen Access
    Nature
    Volume: 619, P: 819-827
  • Human proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce viral infectivity. Here, the authors show that SERINC3 has architecture resembling non-ATP dependent lipid transporters and induces loss of membrane asymmetry correlated with changes in envelope conformation and loss of infectivity.

    • Susan A. Leonhardt
    • Michael D. Purdy
    • Mark Yeager
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Algorithms that account for and overcome the intrinsic pixel-dependent readout noise from scientific complementary metal-oxide semiconductor (sCMOS) cameras prevent localization artifacts and avoid substantial compromises in localization uncertainty in single-molecule imaging. When combined with multi-emitter fitting, sCMOS cameras allow video-rate single-molecule switching nanoscopy.

    • Fang Huang
    • Tobias M P Hartwich
    • Joerg Bewersdorf
    Research
    Nature Methods
    Volume: 10, P: 653-658