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Correction: Publisher Correction: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Adekunle T. Bademosi
Elsa Lauwers
Frédéric A. Meunier
Amendments and CorrectionsOpen Access10 Apr 2018
Nature Communications

Volume: 9, P: 1
Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Adekunle T. Bademosi
Elsa Lauwers
Frédéric A Meunier
Amendments and CorrectionsOpen Access09 Feb 2017
Nature Communications

Volume: 8, P: 1
Emergent properties of the interferon-signalling network may underlie the success of hepatitis C treatment

The standard treatment for hepatitis C virus (HCV) infection, combining interferon (IFN) α and ribavirin, fails in a number of patients. Here, the authors use a mathematical model of the IFN signalling network in the presence of HCV to explain the success or failure of hepatitis C treatment.

Pranesh Padmanabhan
Urtzi Garaigorta
Narendra M. Dixit
Research16 May 2014
Nature Communications

Volume: 5, P: 1-9
FTO suppresses DNA repair by inhibiting PARP1

Maintaining genomic integrity is essential for the survival of organisms. Here, the authors identify FTO as an endogenous negative regulator of PARP1 and the DNA damage response in cells beyond its role as an RNA demethylase.

Tianyi Zhu
Jing Zhi Anson Tan
Victor Anggono
ResearchOpen Access25 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Modeling how antibody responses may determine the efficacy of COVID-19 vaccines

A multiscale model is presented to quantitatively predict COVID-19 vaccine efficacies by describing the generation, activity and diversity of neutralizing antibodies.

Pranesh Padmanabhan
Rajat Desikan
Narendra M. Dixit
Research28 Feb 2022
Nature Computational Science

Volume: 2, P: 123-131
In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Syntaxin1A (Sx1A) is organized in nanoclusters in neurosecretory cells but how these nanoclusters are affected by neurotransmitter release in a living organism is unknown. Here the authors perform single molecule imaging analysis in live fly larvae and show that the lateral diffusion and trapping of Sx1A in nanoclusters are altered by synaptic activity.

Adekunle T. Bademosi
Elsa Lauwers
Frédéric A. Meunier
ResearchOpen Access16 Dec 2016
Nature Communications

Volume: 7, P: 1-17
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado et al. show that SARS-CoV-2 induces senescence in human brain organoids and in the brains of COVID-19-infected mice and humans. They demonstrate the therapeutic potential of senolytic therapy in protection against COVID-19-induced brain aging.

Julio Aguado
Alberto A. Amarilla
Ernst J. Wolvetang
ResearchOpen Access13 Nov 2023
Nature Aging

Volume: 3, P: 1561-1575
Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy

Success in a trial of low-intensity ultrasound combined with an amyloid-β antibody represents a major stride towards integrating pharmacological and nonpharmacological approaches to reduce the amyloid-β load in patients with mild Alzheimer disease. This trial also highlights the potential of therapeutic ultrasound modalities to combat neurodegenerative diseases.

Jürgen Götz
Pranesh Padmanabhan
News & Views20 Feb 2024
Nature Reviews Neurology

Volume: 20, P: 257-258
Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease

Synaptic dysfunction is a key feature of Alzheimer disease. In this Review, Padmanabhan, Kneynsberg and Götz examine insights provided by super-resolution microscopy into synaptic architecture and organization in Alzheimer disease, focusing on amyloid-β and tau, thought to be two key players in the pathophysiology of the disease.

Pranesh Padmanabhan
Andrew Kneynsberg
Jürgen Götz
Reviews01 Nov 2021
Nature Reviews Neuroscience

Volume: 22, P: 723-740
Clinical relevance of animal models in aging-related dementia research

This Perspective describes the clinical relevance of animal models in dementia for translational research. The authors emphasize incorporating aging as a component in model organisms to understand its contribution to disease pathogenesis.

Pranesh Padmanabhan
Jürgen Götz
Reviews18 May 2023
Nature Aging

Volume: 3, P: 481-493
Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules

This protocol describes a pulse–chase approach to studying activity-dependent internalization of fluorescent ligands into endocytic compartments using subdiffractional single-particle tracking in live hippocampal neurons.

Merja Joensuu
Ramon Martínez-Mármol
Frédéric A Meunier
Protocols30 Nov 2017
Nature Protocols

Volume: 12, P: 2590-2622

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Correction: Publisher Correction: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Emergent properties of the interferon-signalling network may underlie the success of hepatitis C treatment

FTO suppresses DNA repair by inhibiting PARP1

Modeling how antibody responses may determine the efficacy of COVID-19 vaccines

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy

Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease

Clinical relevance of animal models in aging-related dementia research

Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules

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