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Showing 1–20 of 20 results
Advanced filters: Author: Qiandong Zeng Clear advanced filters

  • The three-dimensional structure of the N-terminal domain of an archaeal TFIIB, which has high sequence homology with eucaryal analogues, is strikingly similar to that of the C-terminal zinc ribbon of the eucaryal transcription elongation factor TFIIS.

    • Wenlian Zhu
    • Qiandong Zeng
    • Robert A. Scott
    Correspondence
    Nature Structural Biology
    Volume: 3, P: 122-124

  • Mid-infrared 2 μm InAs/InP quantum-dot lasers is first demonstrated, with a low threshold current density of 118 A cm−2 per layer and a maximum operating temperature of 50 °C.

    • Yangqian Wang
    • Hui Jia
    • Huiyun Liu
    ResearchOpen Access
    Light: Science & Applications
    Volume: 15, P: 1-12

  • Accurate, phased assemblies are a key tool in understanding the human genome, particularly in highly polymorphic regions like the medically important MHC. Here the authors provide an assembly-based benchmark for this difficult-to-characterize region.

    • Chen-Shan Chin
    • Justin Wagner
    • Justin M. Zook
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Pneumocystis jirovecii is a fungus that can cause life-threatening pneumonia in immunocompromised patients. Here, the authors sequence the genomes of P. jirovecii and two other Pneumocystisspecies, and show the unexpected absence of chitin (a near universal fungal cell wall component).

    • Liang Ma
    • Zehua Chen
    • Joseph A. Kovacs
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Microsporidia are intracellular parasitic fungi that infect diverse animal hosts including humans. Here, Desjardins et al.present genomic and transcriptomic data for two microsporidia that infect disease-transmitting mosquitoes, highlighting differences in potential host interplay mechanisms.

    • Christopher A. Desjardins
    • Neil D. Sanscrainte
    • Christina A Cuomo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Fungi from the genus Fusarium are important pathogens of animals and crop plants. Some have a wide host range, whereas others are more specific in the organisms they infect. Here, clues are provided as to how differences in specificity come about. The genomes of two Fusarium fungi with differing host ranges have been sequenced, and compared with the genome of a third species. Experiments show that transferring two whole chromosomes turns a non-pathogenic Fusarium strain into a pathogenic one.

    • Li-Jun Ma
    • H. Charlotte van der Does
    • Martijn Rep
    ResearchOpen Access
    Nature
    Volume: 464, P: 367-373

  • Candida species are the most common cause of opportunistic fungal infection worldwide. Here, the genomes of six Candida species are sequenced and compared with each other and with related pathogens and non-pathogens; providing insight into the genetic features that underlie the diversity of Candida biology, including pathogenesis and the architecture of mating and meiotic processes.

    • Geraldine Butler
    • Matthew D. Rasmussen
    • Christina A. Cuomo
    ResearchOpen Access
    Nature
    Volume: 459, P: 657-662

  • Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

    • Monika Gulia-Nuss
    • Andrew B. Nuss
    • Catherine A. Hill
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Reconstructing full-length transcripts from high-throughput RNA sequencing data is difficult without a reference genome sequence. Grabherr et al. describe Trinity, an algorithm for assembling full-length transcripts from short reads without first mapping the reads to a genome sequence.

    • Manfred G Grabherr
    • Brian J Haas
    • Aviv Regev
    Research
    Nature Biotechnology
    Volume: 29, P: 644-652

  • Thomas Nutman and colleagues report the draft genome of the filarial pathogen Loa loa, the African eyeworm. They also report coverage of two other filarial pathogens, Wuchereria bancrofti and Onchocerca volvulus. Unlike most filariae, L. loa lacks an obligate intracellular Wolbachia endosymbiont, and comparative genomic analyses suggest that the L. loa genome does not contain new metabolic synthesis or transport pathways compared to other filariae.

    • Christopher A Desjardins
    • Gustavo C Cerqueira
    • Thomas B Nutman
    ResearchOpen Access
    Nature Genetics
    Volume: 45, P: 495-500

  • The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

    • Barbara A. Methé
    • Karen E. Nelson
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 215-221

  • The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

    • Curtis Huttenhower
    • Dirk Gevers
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 207-214

  • Richard O'Connell and colleagues report the genomes and transcriptomes of two Colletotrichum plant fungal pathogens. C. higginsianum infects Arabidopsis thaliana, and C. graminicola infects maize (Zea mays); comparative genomics in both species lead to molecular insights into the transition from biotrophic to necrotrophic life stages.

    • Richard J O'Connell
    • Michael R Thon
    • Lisa J Vaillancourt
    ResearchOpen Access
    Nature Genetics
    Volume: 44, P: 1060-1065

  • Zhang, Yang et al. compare a Fusarium oxysporum isolate obtained clinically to a phytopathogenic strain to examine transfer of lineage-specific chromosomes in determining host specificity. They find four unique lineage-specific chromosomes that seem to contribute to fungal adaptation to human hosts.

    • Yong Zhang
    • He Yang
    • Li-Jun Ma
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-12