Metabolic disorder significantly contributes to diabetic vascular complications, including diabetic retinopathy (DR). This study reveals that O-GlcNAcylation, a nutrient-sensitive protein modification, drives vascular dysfunction in DR by stabilizing Hippo signaling key components YAP/TAZ. Targeting O-GlcNAc-YAP/TAZ shows therapeutic potential for mitigating DR pathology.
- Yi Lei
- Qiangyun Liu
- Xiaohong Wang
