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Signal Transduction and Targeted Therapy (4)
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Advanced filters: Author: Qingnan Wu Clear advanced filters

Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis

Jie Chen
Jing Zhang
Qimin Zhan
ResearchOpen Access01 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-16
Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy

Necroptosis in cancer cells remains incompletely understood. Here, the authors show that inhibition of FGFR2 could induce necroptosis via crosstalk between the NF2-Hippo-YAP and RIP1-MST1-MLKL pathways and shapes an immunosuppressive tumor microenvironment.

Dongshao Chen
Zitong Zhao
Qimin Zhan
ResearchOpen Access03 May 2025
Nature Communications

Volume: 16, P: 1-18
Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling

The retina is a heterogeneous tissue composed of multiple cell types. Via single-nuclei RNA sequencing on human neural retinal tissue, the authors characterise the transcriptome profile for individual cell types in the human retina.

Qingnan Liang
Rachayata Dharmat
Rui Chen
ResearchOpen Access17 Dec 2019
Nature Communications

Volume: 10, P: 1-12
Enhanced bending strength and thermal conductivity in diamond/Al composites with B₄C coating

Youhong Sun
Chi Zhang
Jinhao Wu
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-12
Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits

Xingyang Liu
Qinjie Min
Qimin Zhan
ResearchOpen Access11 Oct 2024
British Journal of Cancer

Volume: 131, P: 1591-1604
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia

Xu Chen
Qingnan Wu
Qimin Zhan
ResearchOpen Access26 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-16
AKT2^S128/CCTα^S315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

Jie Chen
Lingyuan Zhang
Qimin Zhan
ResearchOpen Access28 Jan 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties

Mengzhu Lv
Ying Gong
Qimin Zhan
ResearchOpen Access16 Aug 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-19
Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)

Jie Chen
Di Zhao
Qimin Zhan
ResearchOpen Access12 Aug 2022
Cellular & Molecular Immunology

Volume: 19, P: 1054-1066
A deep learning integrated radiomics model for identification of coronavirus disease 2019 using computed tomography

Xiaoguo Zhang
Dawei Wang
Zhongfa Zhang
ResearchOpen Access16 Feb 2021
Scientific Reports

Volume: 11, P: 1-12