Nature Search

Coupled modeling framework for proactive design of debris-flow barrier placements

Deuk-Hwan Lee
Seung-Rae Lee
Joon-Young Park
ResearchOpen Access01 Oct 2025
Scientific Reports

Volume: 15, P: 1-22
Base editing of haematopoietic stem cells rescues sickle cell disease in mice

A custom adenine base editor can edit the variant of the β-globin gene that causes sickle cell disease into a non-pathogenic variant in human and mouse cells, and transplantation of the edited cells rescues sickle cell disease in mice.

Gregory A. Newby
Jonathan S. Yen
David R. Liu
Research02 Jun 2021
Nature

Volume: 595, P: 295-302
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Optimization of cytidine and adenine base editors increases editing efficiency.

Luke W Koblan
Jordan L Doman
David R Liu
Research29 May 2018
Nature Biotechnology

Volume: 36, P: 843-846
Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome

This study identified prevalent giant extrachromosomal elements from the human oral microbiome. The genetic and ecological analysis provides insight on the potential contribution of this element in adaptation against multiple oral environmental stressors.

Yuya Kiguchi
Nagisa Hamamoto
Yutaka Suzuki
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Wider editing windows and different PAM requirements enable a broad set of genomic positions to be targeted with A and C base editors.

Tony P. Huang
Kevin T. Zhao
David R. Liu
Research20 May 2019
Nature Biotechnology

Volume: 37, P: 626-631
Universal toxin-based selection for precise genome engineering in human cells

Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in vivo.

Songyuan Li
Nina Akrap
Marcello Maresca
ResearchOpen Access21 Jan 2021
Nature Communications

Volume: 12, P: 1-14
Reconstruction of evolving gene variants and fitness from short sequencing reads

Using short-read sequencing data, Evoracle reconstructs full-length genotypes and fitness during directed evolution experiments, and can identify low-frequency variants before they can be identified using consensus mutations.

Max W. Shen
Kevin T. Zhao
David R. Liu
Research11 Oct 2021
Nature Chemical Biology

Volume: 17, P: 1188-1198
Basin-scale reconstruction of euxinia and Late Devonian mass extinctions

A spatial and temporal compilation of geochemical data documents a stepwise transgression of toxic euxinic waters into shallow oceans that drove a series of Late Devonian extinction events.

Swapan K. Sahoo
Geoffrey J. Gilleaudeau
Alan J. Kaufman
Research08 Mar 2023
Nature

Volume: 615, P: 640-645
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit melanomagenesis in mice.

Shuyang Chen
Changpeng Han
Rutao Cui
ResearchOpen Access20 Feb 2019
Nature Communications

Volume: 10, P: 1-10
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.

Megan J. R. Yeo
Olivia Zhang
Ning Zheng
ResearchOpen Access12 Feb 2025
Nature

Volume: 639, P: 232-240
Lethal Effect of Indolyl-3-Acetic Acid Ethyl Ester and Protective Effect of Indolyl-3-Acetic Acid on Free Cells of the Ehrlich Ascites Carcinoma

R. D. SCHULTZ
D. NORMAN
Research11 May 1963
Nature

Volume: 198, P: 553-554
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

Two approaches using an adenine base editor and a Cas9 nuclease prevented the development of hypertrophic cardiomyopathy in mice carrying a pathogenic mutation on the Myh6 gene, highlighting the potential of single-dose genetic therapies for the treatment of cardiac disease.

Daniel Reichart
Gregory A. Newby
Christine Seidman
ResearchOpen Access16 Feb 2023
Nature Medicine

Volume: 29, P: 412-421
Simplifying multidimensional fermentation dataset analysis and visualization: One step closer to capturing high-quality mutant strains

Xiang Zhou
Dan Xu
Ting-Ting Jiang
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Direct correction of haemoglobin E β-thalassaemia using base editors

The authors demonstrate efficient and direct correction of the DNA mutation causing Haemoglobin E β-thalassaemia with CRISPR Cas9 base editors. The work includes profiling of off-target effects using deep neural networks.

Mohsin Badat
Ayesha Ejaz
James O. J. Davies
ResearchOpen Access19 Apr 2023
Nature Communications

Volume: 14, P: 1-7
Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Improved cytosine base editors are generated by phage-assisted evolution of a deoxyadenosine deaminase.

Monica E. Neugebauer
Alvin Hsu
David R. Liu
ResearchOpen Access10 Nov 2022
Nature Biotechnology

Volume: 41, P: 673-685
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

A systematic implementation of six efficiency optimizations for prime editing led to high levels of functional correction, in airway epithelial cells, of the predominant mutation that causes cystic fibrosis.

Alexander A. Sousa
Colin Hemez
David R. Liu
ResearchOpen Access10 Jul 2024
Nature Biomedical Engineering

Volume: 9, P: 7-21
THE BODY'S CHEMICAL MECHANISMS OF DEFENCE*

C. R. HARINGTON
Research08 Mar 1947
Nature

Volume: 159, P: 319-320
Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation

Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte excitability, representing a potential target in treating cardiac diseases.

Zifan Pei
Yucheng Xiao
Theodore R. Cummins
ResearchOpen Access23 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Base editor treats progeria in mice

A single dose of an adenine base editor shows promise in treating the ageing-related disease Hutchinson–Gilford progeria syndrome. It corrected the LMNA mutation underlying the disease in patient-derived cells and improved cardiovascular health and lifespan in mice.

Luke W. Koblan
Michael R. Erdos
David R. Liu
News & Views18 Jun 2021
Nature
Scalable biological signal recording in mammalian cells using Cas12a base editors

A DNA recording method based on an enhanced dCas12a base editor system enables the parallel and scalable recording of cellular signaling events in multiple mammalian cell types.

Hannah R. Kempton
Kasey S. Love
Lei S. Qi
Research30 May 2022
Nature Chemical Biology

Volume: 18, P: 742-750
Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

Methods to efficiently detect Cas9-independent cytosine base editor off-target activity enable the identification and development of variants with minimal off-target editing and robust on-target editing.

Jordan L. Doman
Aditya Raguram
David R. Liu
Research10 Feb 2020
Nature Biotechnology

Volume: 38, P: 620-628
Evolution of intrinsic disorder in the structural domains of viral and cellular proteomes

Fizza Mughal
Gustavo Caetano-Anollés
ResearchOpen Access22 Jan 2025
Scientific Reports

Volume: 15, P: 1-19
Base editing: precision chemistry on the genome and transcriptome of living cells

Genome editing through direct editing of bases holds promise for achieving precise genomic changes at single-nucleotide resolution while minimizing the occurrence of potentially mutagenic double-strand DNA breaks. In this Review, Rees and Liu provide a comprehensive account of the state of the art of base editing of DNA and RNA, including the progressive improvements to methodologies, understanding and avoiding unintended edits, cellular and organismal delivery of editing reagents and diverse applications in research and therapeutic settings.

Holly A. Rees
David R. Liu
Reviews15 Oct 2018
Nature Reviews Genetics

Volume: 19, P: 770-788
In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice

Hemochromatosis is a metabolic disorder caused by mutations in the HFE gene. Here, the authors show that a single administration of AAV8 vectors expressing an Adenine Base Editor facilitates efficient in vivo gene correction in hepatocytes and leads to improvement of iron-specific parameters in the liver and the blood in mouse models of the disease.

Alice Rovai
BoMee Chung
Michael Ott
ResearchOpen Access05 Sept 2022
Nature Communications

Volume: 13, P: 1-10
Precision genome editing using cytosine and adenine base editors in mammalian cells

This protocol for base editing in cultured mammalian cells provides guidelines for choosing target sites, appropriate base editor variants and delivery strategies, as well as detailing the computational analysis of base-editing outcomes using CRISPResso2.

Tony P. Huang
Gregory A. Newby
David R. Liu
Protocols18 Jan 2021
Nature Protocols

Volume: 16, P: 1089-1128
Changes in frequency–size relationship from small to large earthquakes

Javier F. Pacheco
Christopher H. Scholz
Lynn R. Sykes
Research02 Jan 1992
Nature

Volume: 355, P: 71-73
Silver-110m and Cobalt-60 in Oceanic and Coastal Organisms

T. R. FOLSOM
D. R. YOUNG
Research22 May 1965
Nature

Volume: 206, P: 803-806
Palmitoylation-dependent activation of MC1R prevents melanomagenesis

The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.

Shuyang Chen
Bo Zhu
Rutao Cui
Research06 Sept 2017
Nature

Volume: 549, P: 399-403
Beryllium-free Li₄Sr(BO₃)₂ for deep-ultraviolet nonlinear optical applications

Deep-ultraviolet nonlinear optical materials can generate laser light below 200 nm, which is crucial to solid-state deep-ultraviolet lasers. Here, the authors find that Li₄Sr(BO₃)₂shows advantageous properties as a deep-ultraviolet nonlinear optical material, where alternatives are rare.

Sangen Zhao
Pifu Gong
Junhua Luo
Research29 May 2014
Nature Communications

Volume: 5, P: 1-7
Generation of Aerosols by Vapour-Phase Polymerization of Methyl Acrylate

R. PEARSON
G. LANGER
Research16 Jul 1960
Nature

Volume: 187, P: 235
Spatial and temporal control of gene therapy using ionizing radiation

Dennis E. Hallahan
Helena J. Mauceri
Ralph R. Weichselbaum
Research01 Aug 1995
Nature Medicine

Volume: 1, P: 786-791
Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput

Combining genome-wide CRISPR–Cas9-mediated base editors with temporally resolved phosphoproteomics enables the functional screening of thousands of post-translational modification sites involved in T cell activation.

Patrick H. Kennedy
Amin Alborzian Deh Sheikh
Samuel A. Myers
Research29 Apr 2024
Nature Methods

Volume: 21, P: 1033-1043
Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference

Existing TadA-derived CBEs exhibit residual A•T-to-G•C editing activity and suffer from lower activity at several sequence contexts and with non-SpCas9 targeting domains. Here, the authors use phage-assisted evolution to evolve CBE6 variants that address these limitations.

Emily Zhang
Monica E. Neugebauer
David R. Liu
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-13
ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation

Adam Sheriff
Ina Guri
Joanna Jacków
ResearchOpen Access16 Nov 2022
Scientific Reports

Volume: 12, P: 1-16
The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene

Jingshi Wu
John R. Forbes
Diane W. Cox
Research01 Aug 1994
Nature Genetics

Volume: 7, P: 541-545
Tissue Typing in Man

ARNOLD R. SANDERSON
Research01 Jul 1967
Nature

Volume: 215, P: 23-25
Analysis and prediction of protein β-sheet structures by a combinatorial approach

Fred E. Cohen
Michael J. E. Sternberg
William R. Taylor
Research05 Jun 1980
Nature

Volume: 285, P: 378-382
Secure random number generation from parity symmetric radiations

Random number generators (RNGs) are indispensable tools for information security. The authors derive a security proof for a quantum RNG based on parity-symmetric radioactive decay, which can be made as small as a few-square-millimeter chip and whose source has no need for power generation.

Toyohiro Tsurumaru
Toshihiko Sasaki
Izumi Tsutsui
ResearchOpen Access01 Jul 2022
Communications Physics

Volume: 5, P: 1-8
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

A growing arsenal of CRISPR-based tools enables increasingly sophisticated genome editing applications.

Andrew V. Anzalone
Luke W. Koblan
David R. Liu
Reviews22 Jun 2020
Nature Biotechnology

Volume: 38, P: 824-844
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis

Yan et al. report that breast cancer cell-derived miR-122 downregulates O-GlcNAcylation of RYR1 and increases its abundance, thereby leading to dysregulated skeletal muscle proteolysis with aberrant Ca²⁺ levels and calpain protease activation.

Wei Yan
Minghui Cao
Shizhen Emily Wang
Research25 Apr 2022
Nature Cell Biology

Volume: 24, P: 793-804
Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

James A.R. Nicoll
Gareth W. Roberts
David I. Graham
Research01 Feb 1995
Nature Medicine

Volume: 1, P: 135-137
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

Efficiency of transversion base editing is increased by matching a set of base editors to target sequences.

Luke W. Koblan
Mandana Arbab
David R. Liu
Research28 Jun 2021
Nature Biotechnology

Volume: 39, P: 1414-1425
Alfvén waves generated by an inverted plasma energy distribution

W. J. HUGHES
D. J. SOUTHWOOD
J. N. BARFIELD
Research07 Sept 1978
Nature

Volume: 275, P: 43-45
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis

The authors uncover the roles and regulations of DNA polymerase κ (Polκ) during DNA damage bypass. In addition to a catalytic function across minor groove DNA lesions, Polκ stimulates Polζ-mediated extension past various DNA lesions.

Selene Sellés-Baiget
Sara M. Ambjørn
Julien P. Duxin
ResearchOpen Access19 Sept 2024
Nature Structural & Molecular Biology

Volume: 32, P: 300-314
Mixed Saliva from Sheep

W. R. McMANUS
Research23 Dec 1961
Nature

Volume: 192, P: 1161-1163
Search for superheavy elements in monazites using chemical enrichment

R. Stakemann
R. Heimann
N. Trautmann
Research13 May 1982
Nature

Volume: 297, P: 136-138
Chromosomal localization of human cellular homologues of two viral oncogenes

Nora Heisterkamp
John Groffen
W. F. Bodmer
Research21 Oct 1982
Nature

Volume: 299, P: 747-749
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

A new base editor enables the creation of C-to-G base changes in human cells.

Ibrahim C. Kurt
Ronghao Zhou
J. Keith Joung
Research20 Jul 2020
Nature Biotechnology

Volume: 39, P: 41-46
Mental Stress and Acute Dental Caries

PHILIP R. N. SUTTON
Research21 Jul 1962
Nature

Volume: 195, P: 254-256
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

The ability to genetically modify haematopoietic stem cells would allow the durable treatment of a diverse range of genetic disorders but gene delivery to the bone marrow has not been achieved. Here lipid nanoparticles that target and deliver mRNA to 14 unique cells within the bone marrow are presented.

Xizhen Lian
Sumanta Chatterjee
Daniel J. Siegwart
Research23 May 2024
Nature Nanotechnology

Volume: 19, P: 1409-1417

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