Nature Search

ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

M Mousli
R Hopfner
C Bronner
ResearchOpen Access01 Jul 2003
British Journal of Cancer

Volume: 89, P: 120-127
The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling

X-ray crystal structures and mutational analysis of the Arp8 module of the yeast chromatin remodeler INO80 reveal its function as a linker DNA sensor required for nucleosome positioning.

Kilian R. Knoll
Sebastian Eustermann
Karl-Peter Hopfner
Research03 Sept 2018
Nature Structural & Molecular Biology

Volume: 25, P: 823-832
Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

Kurt Farrell
Jack Humphrey
Adam Naj
Amendments and CorrectionsOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-2
Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Stefano Romano
George M. Savva
Arjan Narbad
ResearchOpen Access10 Mar 2021
npj Parkinson's Disease

Volume: 7, P: 1-13
The impact of ammonia on particle formation in the Asian Tropopause Aerosol Layer

Christos Xenofontos
Matthias Kohl
Theodoros Christoudias
ResearchOpen Access12 Sept 2024
npj Climate and Atmospheric Science

Volume: 7, P: 1-12
Rational engineering of activity and specificity in a serine protease

Quoc D. Dang
Enriqueta R. Guinto
Enrico Di Cera
Research01 Feb 1997
Nature Biotechnology

Volume: 15, P: 146-149
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Madhurima Chatterjee
Selcuk Özdemir
Anja Schneider
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 1771-1783
MDR1 gene expression in primary colorectal carcinomas

R Pirker
J Wallner
D Depisch
Research01 Oct 1993
British Journal of Cancer

Volume: 68, P: 691-694
An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses

An Oryza-specific histone H4 variant (H4.V) forms condensed, less stable nucleosomes. H4.V enhances the salt-stress-dependent deposition of H4 lysine 5 acetylation marks at several protein-coding loci, thereby regulating the salt stress transcriptome.

Vivek Hari-Sundar Gandhivel
Paula Sotelo-Parrilla
P. V. Shivaprasad
Research08 Apr 2025
Nature Plants

Volume: 11, P: 790-807
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

The authors present the largest genome-wide association study to date for a rare Parkinsonian disorder, progressive supranuclear palsy (PSP). They include follow-up investigations of the identified susceptibility loci, functional consequences, and cell-specific pathologies, providing insights into genetic and molecular mechanisms underlying PSP.

Kurt Farrell
Jack Humphrey
Adam Naj
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Measuring DNA mechanics on the genome scale

A high-throughput, chromosome-wide analysis of DNA looping reveals its contribution to the organization of chromatin, and provides insight into how nucleosomes are deposited and organised de novo.

Aakash Basu
Dmitriy G. Bobrovnikov
Taekjip Ha
Research16 Dec 2020
Nature

Volume: 589, P: 462-467
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

Johannes Schumacher and colleagues report the results of a genetic association study of idiopathic achalasia, a rare motility disorder of the esophagus. They show that common variation in the HLA-DQ region is strongly associated with achalasia risk, implicating immune-mediated processes in this disorder.

Ines Gockel
Jessica Becker
Johannes Schumacher
Research06 Jul 2014
Nature Genetics

Volume: 46, P: 901-904
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity

RAB-11-positive recycling endosomes participate in the establishment and maintenance of epithelial polarity. Zerial and colleagues carry out an in vivo image-based RNAi screen for factors that regulate recycling endosome positioning in Caenorhabditis elegans. They identify, among other candidates, PAR-5 as a key determinant of recycling endosome positioning and, thus, apicobasal polarity.

Julia Franziska Winter
Sebastian Höpfner
Marino Zerial
Research27 May 2012
Nature Cell Biology

Volume: 14, P: 666-676
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Multi-ancestry genome-wide association analyses identify new risk loci for Parkinson’s disease, and fine-mapping and co-localization analyses implicate candidate genes whose expression is associated with disease susceptibility.

Jonggeol Jeffrey Kim
Dan Vitale
Ignacio Mata
ResearchOpen Access28 Dec 2023
Nature Genetics

Volume: 56, P: 27-36
Regulation of survivin expression by IGF-1/mTOR signaling

V Vaira
C W Lee
D C Altieri
Research30 Oct 2006
Oncogene

Volume: 26, P: 2678-2684
Novel compounds with antiangiogenic and antiproliferative potency for growth control of testicular germ cell tumours

B Nitzsche
C Gloesenkamp
M Höpfner
ResearchOpen Access15 Jun 2010
British Journal of Cancer

Volume: 103, P: 18-28
The role of signaling pathways in the development and treatment of hepatocellular carcinoma

S Whittaker
R Marais
A X Zhu
Reviews19 Jul 2010
Oncogene

Volume: 29, P: 4989-5005
Insights into ancestral diversity in Parkinson’s disease risk: a comparative assessment of polygenic risk scores

Paula Saffie-Awad
Spencer M. Grant
Sara Bandres-Ciga
ResearchOpen Access03 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-13
Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

A mycobacterial phosphodiesterase, CdnP, hydrolyzes bacteria-derived 3′,5′-c-di-AMP as well as host-generated 2′,3′-cGAMP, which activates the host cytosolic surveillance pathway, to dampen host responses.

Ruchi Jain Dey
Bappaditya Dey
William R Bishai
Research12 Dec 2016
Nature Chemical Biology

Volume: 13, P: 210-217
Structural basis of ligand binding by a c-di-GMP riboswitch

The GEMM riboswitch is conserved in diverse bacteria and recognizes the second messenger c-di-GMP which mediates many processes, such as the transition between sedentary and motile behavior. The structure of the GEMM riboswitch with ligand now elucidates ligand recognition and specificity.

Kathryn D Smith
Sarah V Lipchock
Scott A Strobel
Research08 Nov 2009
Nature Structural & Molecular Biology

Volume: 16, P: 1218-1223
The shunt problem: control of functional shunting in normal and tumour vasculature

This Opinion article discusses how aberrant vascular remodelling might lead to tumour hypoxia. What controls this process, and could this be reversed — or normalized — by anti-angiogenic therapies?

Axel R. Pries
Michael Höpfner
Timothy W. Secomb
Reviews15 Jul 2010
Nature Reviews Cancer

Volume: 10, P: 587-593
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

This study identifies regulators of the RNA sensor RIG-I. Diverse processes, including the unfolded protein response, Wnt signalling and RNA metabolism, modulate this pathway. The splicing regulator KHSRP is identified as a negative regulator of RIG-I that affects influenza replication in vivo.

Stephen Soonthornvacharin
Ariel Rodriguez-Frandsen
Sumit K. Chanda
Research01 Mar 2017
Nature Microbiology

Volume: 2, P: 1-13
Immunocytochemical detection of the multidrug resistance-associated protein and P-glycoprotein in acute myeloid leukemia: impact of antibodies, sample source and disease status

M Filipits
RW Suchomel
R Pirker
Research01 Jul 1997
Leukemia

Volume: 11, P: 1073-1077
Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas

M Fillpits
RW Suchomel
R Pirker
Research01 Jan 1997
British Journal of Cancer

Volume: 75, P: 208-212
Adjuvant treatment with cyclosporin A increases the toxicity of chemotherapy for remission induction in acute non-lymphocytic leukemia

D Damiani
M Michieli
M Baccarani
Research12 Aug 1998
Leukemia

Volume: 12, P: 1236-1240
UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer

M Unoki
J D Kelly
R Hamamoto
ResearchOpen Access02 Jun 2009
British Journal of Cancer

Volume: 101, P: 98-105
UHRF1 is a novel diagnostic marker of lung cancer

M Unoki
Y Daigo
Y Nakamura
ResearchOpen Access01 Jun 2010
British Journal of Cancer

Volume: 103, P: 217-222
The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

Lara M. Lange
Kristin Levine
Masharip Atadzhanov
ResearchOpen Access25 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase π gene expression in primary and relapsed state adult and childhood leukaemias

V Gekeler
G Frese
D Niethammer
Research01 Sept 1992
British Journal of Cancer

Volume: 66, P: 507-517
Comparative evaluation by semiquantitative reverse transcriptase polymerase chain reaction of MDR1, MRP and GSTp gene expression in breast carcinomas

R Lacave
F Coulet
JF Bernaudin
Research01 Mar 1998
British Journal of Cancer

Volume: 77, P: 694-702
Cyclosporin A and doxorubicin-ifosfamide in resistant solid tumours: a phase I and an immunological study

R González-Manzano
J Cid
CC Piasecki
Research01 Nov 1995
British Journal of Cancer

Volume: 72, P: 1294-1299
Desmoids in familial adenomatous polyposis are monoclonal proliferations

S B Middleton
I M Frayling
R K S Phillips
ResearchOpen Access20 Jan 2000
British Journal of Cancer

Volume: 82, P: 827-832
Author Correction: Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)

Lara M. Lange
Micol Avenali
Masharip Atadzhanov
Amendments and CorrectionsOpen Access13 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-3
Pharmacogenetics of anticancer drugs in non-Hodgkin lymphomas

L Loni
M Del Tacca
R Danesi
ReviewsOpen Access13 Nov 2001
British Journal of Cancer

Volume: 85, P: 1425-1431
Identification and functional analysis of 9p24 amplified genes in human breast cancer

J Wu
S Liu
Z-Q Yang
Research13 Jun 2011
Oncogene

Volume: 31, P: 333-341
Transformation of Breast Reconstruction via Additive Biomanufacturing

Mohit P. Chhaya
Elizabeth R. Balmayor
Jan-Thorsten Schantz
ResearchOpen Access15 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns
Madeleine Richer
Masharip Atadzhanov
ResearchOpen Access12 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-6
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample

M Koch
S Freitag-Wolf
W Lieb
Research05 Apr 2017
European Journal of Clinical Nutrition

Volume: 71, P: 995-1001

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