Nature Search

Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota

The PLate Coverage Algorithm (PLCA) determines the culture plates required for culture-enriched metagenomics and enables the recovery of greater taxonomic diversity, better quality metagenome-assembled genomes and improved functional annotations compared to metagenomics alone, indicating its utility for other microbiomes, especially those dominated by host DNA.

Fiona J. Whelan
Barbara Waddell
Michael G. Surette
Research20 Jan 2020
Nature Microbiology

Volume: 5, P: 379-390
Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA modification and localization relate to disease pathogenesis.

Thai B. Nguyen
Ricardo Miramontes
Leslie M. Thompson
ResearchOpen Access06 Jan 2025
Nature Neuroscience

Volume: 28, P: 280-292
Intercalation of copper metal clusters in montmorillonite

P. B. Malla
P. Ravindranathan
R. Roy
Research13 Jun 1991
Nature

Volume: 351, P: 555-557
Current facts on para-osteo-arthropathy (POA)

A B Rossier
Ph Bussat
H J Hachen
Research01 May 1973
Spinal Cord

Volume: 11, P: 36-78
A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS–FTD

This study identifies a fluid biomarker of TDP-43 dysfunction, a central pathological feature of the ALS–FTD disease spectrum, and demonstrates that such loss of TDP-43 splicing repression occurs presymptomatically.

Katherine E. Irwin
Pei Jasin
Philip C. Wong
ResearchOpen Access26 Jan 2024
Nature Medicine

Volume: 30, P: 382-393
Sonographic diagnosis of heterotopic bone formation in spinal injury patients

V N Cassar-Pullicino
M McClelland
W El Masry
Research01 Jan 1993
Spinal Cord

Volume: 31, P: 40-50
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

In this study, the authors compare the RNA binding patterns of FUS/TLS and TDP-43. Although these proteins regulate the processing of mostly distinct gene products, they do show concurrent regulation of a subset of neuronal transcripts that all have exceptionally long introns.

Clotilde Lagier-Tourenne
Magdalini Polymenidou
Gene W Yeo
Research30 Sept 2012
Nature Neuroscience

Volume: 15, P: 1488-1497
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

The authors identify brain RNA targets for TDP-43, a RNA binding protein linked to ALS. RNAs derived from genes with very long introns were more affected by TDP-43 levels. TDP-43 also auto-regulated its own synthesis, partly by binding and enhancing the splicing of an intron in its 3′ UTR

Magdalini Polymenidou
Clotilde Lagier-Tourenne
Don W Cleveland
Research27 Feb 2011
Nature Neuroscience

Volume: 14, P: 459-468
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

The most common genetic cause of ALS and frontal temporal dementia—hexanucleotide repeat expansion in C9orf72—is shown to provoke disease via synergy of gain of toxicity(ies) from repeat-encoded RNAs/dipeptide repeat proteins and reduction in the C9ORF72 protein.

Qiang Zhu
Jie Jiang
Don W. Cleveland
Research13 Apr 2020
Nature Neuroscience

Volume: 23, P: 615-624
Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

The optimal disambiguation of similar sensory stimuli by neuronal networks is essential to adapt animal behavior. Gschwend and colleagues show that the olfactory bulb network acts as a pattern separator, increasing slight differences between highly related odors. Inhibitory interneuron activation causally improves pattern separation and facilitates odor discrimination learning.

Olivier Gschwend
Nixon M Abraham
Alan Carleton
Research24 Aug 2015
Nature Neuroscience

Volume: 18, P: 1474-1482
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. With unbiased screens in Saccharomyces cerevisiae, Jovicic et al. identified potent modifiers of toxicity of dipeptide repeat proteins produced by unconventional translation of the C9orf72 repeat expansions, pointing to nucleocytoplasmic transport impairments as potential disease mechanisms.

Ana Jovičić
Jerome Mertens
Aaron D Gitler
Research26 Aug 2015
Nature Neuroscience

Volume: 18, P: 1226-1229
Chemolithotrophic processes in the bacterial communities on the surface of mineral-enriched biochars

Jun Ye
Stephen D Joseph
Torsten Thomas
Research07 Feb 2017
The ISME Journal

Volume: 11, P: 1087-1101

Search

Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

Intercalation of copper metal clusters in montmorillonite

Current facts on para-osteo-arthropathy (POA)

A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS–FTD

Sonographic diagnosis of heterotopic bone formation in spinal injury patients

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Chemolithotrophic processes in the bacterial communities on the surface of mineral-enriched biochars

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