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Showing 51–100 of 888 results

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Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19

Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

Lucile P. A. Neyton
Ravi K. Patel
Gabriela K. Fragiadakis
ResearchOpen Access28 Jun 2024
Nature Communications

Volume: 15, P: 1-14
Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice

Leticia Barssotti
Isabel C. M. E. Abreu
Tatiana S. Cunha
ResearchOpen Access28 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Injectable, reversibly thermoresponsive captopril-laden hydrogel for the local treatment of sensory loss in diabetic neuropathy

Amit Chandra Das
James M. Nichols
Jelena M. Janjic
ResearchOpen Access16 Aug 2024
Scientific Reports

Volume: 14, P: 1-18
Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

Mario Fidanza
Julie Hibbert
Amy H. Lee
ResearchOpen Access20 May 2024
Scientific Reports

Volume: 14, P: 1-13
The discovery of a new antibody for BRIL-fused GPCR structure determination

Hikaru Miyagi
Hidetsugu Asada
Jun-ichi Saito
ResearchOpen Access15 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
Breed dependent regulatory mechanisms of beneficial and non-beneficial fatty acid profiles in subcutaneous adipose tissue in cattle with divergent feed efficiency

Mi Zhou
Zhi Zhu
Le Luo Guan
ResearchOpen Access17 Mar 2022
Scientific Reports

Volume: 12, P: 1-16
Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test

Identification of febrile children at risk of death in low-resource settings can improve survival, but tools for their prompt recognition are lacking. Here, the authors show that sTREM-1 measured at clinical presentation predicts in-hospital mortality in febrile children in Uganda.

Aleksandra Leligdowicz
Andrea L. Conroy
Kevin C. Kain
ResearchOpen Access25 Nov 2021
Nature Communications

Volume: 12, P: 1-9
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease

Rational strategies to prioritize candidate biomarkers should save resources and accelerate progress in diagnostics development. Addona et al. integrate proteomics into a pipeline for biomarker validation and use it to identify markers of cardiovascular injury in a scenario where patients serve as their own biological controls.

Terri A Addona
Xu Shi
Steven A Carr
Research19 Jun 2011
Nature Biotechnology

Volume: 29, P: 635-643
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

The hormone aldosterone can damage the heart after myocardial infarction, such that drugs that inhibit its action are often prescribed. B. Julie He et al. now uncover a new pathway underlying the detrimental effects of aldosterone action: oxidation of the enzyme Ca²⁺/calmodulin-dependent protein kinase II leads to its activation and increased expression of the metalloprotease MMP9 in cardiac muscle cells, thereby promoting cardiac rupture.

B Julie He
Mei-ling A Joiner
Mark E Anderson
Research13 Nov 2011
Nature Medicine

Volume: 17, P: 1610-1618
Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin

R Del Giudice
D M Monti
G-F Hu
ResearchOpen Access06 Mar 2014
Cell Death & Disease

Volume: 5, P: e1097
Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy

V Goede
O Coutelle
U T Hacker
ResearchOpen Access05 Oct 2010
British Journal of Cancer

Volume: 103, P: 1407-1414
Relationship between distribution and severity of non-perfusion and cytokine levels and macular thickness in branch retinal vein occlusion

Gahyung Ryu
Donghyoun Noh
Min Sagong
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Immune and inflammatory mechanisms in hypertension

In this Review, Guzik and colleagues discuss immune and inflammatory mechanisms of hypertension, including upstream regulators and downstream effectors as well as the complex interplay between the immune system, blood pressure regulation and end-organ damage, which can help to identify new targets for therapeutic interventions.

Tomasz J. Guzik
Ryszard Nosalski
Grant R. Drummond
Reviews03 Jan 2024
Nature Reviews Cardiology

Volume: 21, P: 396-416
Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

Xia Zhao
Li-ke Zhang
Jun-bao Du
Research01 Aug 2008
Hypertension Research

Volume: 31, P: 1619-1630
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Atsushi Sugimoto
Yoshinobu Saito
Robert F. Schwabe
ResearchOpen Access12 Mar 2025
Nature

Volume: 640, P: 752-761
Differential Medial Temporal Lobe and Parietal Cortical Contributions to Real-world Autobiographical Episodic and Autobiographical Semantic Memory

Thackery I. Brown
Jesse Rissman
Anthony D. Wagner
ResearchOpen Access18 Apr 2018
Scientific Reports

Volume: 8, P: 1-14
Fate of Angiotensin I in the Circulation

K. K. F. NG
J. R. VANE
Research13 Apr 1968
Nature

Volume: 218, P: 144-150
Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

Baoxin Wang
Junjie Yuan
Pin Dong
ResearchOpen Access25 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients

M. A. Slim
E. H. T. Lim
N. P. Juffermans
ResearchOpen Access20 Apr 2024
Scientific Reports

Volume: 14, P: 1-9
Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

Sara R. Selitsky
Jeanette Baran-Gale
Praveen Sethupathy
ResearchOpen Access08 Jan 2015
Scientific Reports

Volume: 5, P: 1-7
Globally elevated chemical weathering rates beneath glaciers

Global glacial chemical denudation is one of the largest contributors to global elemental cycles and, amplified by climate warming, will significantly impact nutrient loads in downstream ecosystems.

Xiangying Li
Ninglian Wang
Guoyu Li
ResearchOpen Access20 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growth

R Sarzani
P Marcucci
A Rappelli
Research18 Sept 2007
International Journal of Obesity

Volume: 32, P: 259-267
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract and is not affected by the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers.

Ivan T. Lee
Tsuguhisa Nakayama
Peter K. Jackson
ResearchOpen Access28 Oct 2020
Nature Communications

Volume: 11, P: 1-14
Uncovering a widely applicable empirical formula for field emission characteristics of metallic nanotips in nanogaps

The authors identified a broadly applicable scaling relationship between field emission characteristics and the ratio of apex radius to gap length, and proposed a modified field emission equation suitable for nanoscale applications.

Yimeng Li
Linghan Xia
Guodong Meng
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-8
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

The chemical honokiol is found in the bark of magnolia trees, which are used for traditional medicine in Asian countries. Here, Pillai et al, show honokiol protects the heart from hypertrophic remodelling in mice, and even reverses established cardiac hypertrophy, by activating the deacetylase Sirt3.

Vinodkumar B. Pillai
Sadhana Samant
Mahesh P. Gupta
Research14 Apr 2015
Nature Communications

Volume: 6, P: 1-16
Systemic delivery of targeted nanotherapeutic reverses angiotensin II-induced abdominal aortic aneurysms in mice

Xiaoying Wang
Vaideesh Parasaram
Naren R. Vyavahare
ResearchOpen Access21 Apr 2021
Scientific Reports

Volume: 11, P: 1-14
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Genetic mechanisms of blood pressure regulation remain poorly defined. Here, the authors perform a kidney multi-omics study to identify 399 kidney effector genes, 11 miRNAs and 97 proteins for blood pressure and hypertension.

Xiaoguang Xu
Chachrit Khunsriraksakul
Maciej Tomaszewski
ResearchOpen Access19 Mar 2024
Nature Communications

Volume: 15, P: 1-29
Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture

Yue Shen
Valerio Russo
David J. Granville
ResearchOpen Access20 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.

T. Azad
H. J. Janse van Rensburg
X. Yang
ResearchOpen Access13 Mar 2018
Nature Communications

Volume: 9, P: 1-15
Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice

Weizu Li
Yanfeng Ding
Rong Ma
ResearchOpen Access23 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels

Mauro G. Silva
Nora L. Falcoff
Mariela M. Gironacci
Research23 Jun 2022
Pediatric Research

Volume: 93, P: 948-952
Neprilysin Inhibitor–Angiotensin II Receptor Blocker Combination Therapy (Sacubitril/valsartan) Suppresses Atherosclerotic Plaque Formation and Inhibits Inflammation in Apolipoprotein E- Deficient Mice

Hui Zhang
Gangqiong Liu
Jinying Zhang
ResearchOpen Access24 Apr 2019
Scientific Reports

Volume: 9, P: 1-7
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

The mechanisms that control blood vessel formation are incompletely understood. Sylvain Chemtob and his colleagues now find that blood vessel formation in mouse and rat retinas is controlled by succinate generated during hypoxic and ischemic conditions. Succinate acting through its receptor, GPR91, on retinal ganglion neurons, triggers secretion of canonical proangiogenic factors and the formation of new blood vessels to reinstate adequate tissue supply. This work also identifies GPR91 as a potential therapeutic target for the treatment of ischemic retinopathies.

Przemyslaw Sapieha
Mirna Sirinyan
Sylvain Chemtob
Research05 Oct 2008
Nature Medicine

Volume: 14, P: 1067-1076
Mediterranean grassland soil C–N compound turnover is dependent on rainfall and depth, and is mediated by genomically divergent microorganisms

Using metagenomics and proteomics on Mediterranean grassland soil samples resulted in the recovery of 793 metagenome-assembled genomes and provided insights into microbial activity in this environment, and how this changes with soil depth and exposure to extended rainfall.

Spencer Diamond
Peter F. Andeer
Jillian F. Banfield
ResearchOpen Access20 May 2019
Nature Microbiology

Volume: 4, P: 1356-1367
Ace revisited: A new target for structure-based drug design

K. Ravi Acharya
Edward D. Sturrock
Mario R. W. Ehlers
Reviews01 Nov 2003
Nature Reviews Drug Discovery

Volume: 2, P: 891-902
Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation

Robbins and colleagues show that cigarette smoke-induced endothelial dysfunction enables atherosclerotic plaque macrophages to drive abdominal aortic aneurysm formation in a mouse model of atherosclerosis.

Danya Thayaparan
Takuo Emoto
Clinton S. Robbins
Research22 Apr 2025
Nature Immunology

Volume: 26, P: 706-721
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Spinal pain is a major clinical problem. Here the authors show that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.

Shuangfei Ni
Zemin Ling
Xu Cao
ResearchOpen Access10 Dec 2019
Nature Communications

Volume: 10, P: 1-15
High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

Venkateswara R. Gogulamudi
Danielle Y. Arita
Minolfa C. Prieto
ResearchOpen Access05 Jul 2021
Scientific Reports

Volume: 11, P: 1-16
Valsartan treatment reverses erectile dysfunction in diabetic rats

Y Chen
S X Li
Y T Dai
Research21 Dec 2006
International Journal of Impotence Research

Volume: 19, P: 366-370
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Xing Du
Xiaolong Ma
Xian Wang
ResearchOpen Access13 Mar 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-16
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Maximilian Jonathan Herzog
Patrick Müller
Ruediger C. Braun-Dullaeus
ReviewsOpen Access01 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-33
Preliminary evidence that blocking the uptake of placenta-derived preeclamptic extracellular vesicles protects the vascular endothelium and prevents vasoconstriction

Lena Erlandsson
Lena Ohlsson
Stefan R. Hansson
ResearchOpen Access27 Oct 2023
Scientific Reports

Volume: 13, P: 1-13
Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo

J D Ahn
R Morishita
I K Lee
Research12 Feb 2004
Gene Therapy

Volume: 11, P: 916-923
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke

Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function and coordinate blood vessel repair following stroke.

Louis-Philippe Bernier
Jasmin K. Hefendehl
Brian A. MacVicar
Research17 Feb 2025
Nature Neuroscience

Volume: 28, P: 517-535
NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

Rongchuan Yue
Zaiyong Zheng
Houxiang Hu
ResearchOpen Access15 Mar 2021
Cell Death Discovery

Volume: 7, P: 1-11
Border-ownership tuning determines the connectivity between V4 and V1 in the macaque visual system

The logic of feedback connectivity in the visual system is largely unknown. Here the authors show that border-ownership tuned cells in V4 have stronger feedback connectivity with V1 cells located in their preferred figure location.

Danique Jeurissen
Anne F. van Ham
Matthew W. Self
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death

Vineet Bhandari
Rayman Choo-Wing
Jack A Elias
Research05 Nov 2006
Nature Medicine

Volume: 12, P: 1286-1293
Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice

How changes in brain blood vessels lead to a chronic reduction in blood flow and, consequently, to vascular dementia is poorly understood. Here, the authors show that venous endothelial dysfunction driven by EPAS1 promotes abnormal vascular remodeling and contributes to cognitive decline.

Vanessa Kristina Wazny
Aparna Mahadevan
Christine Cheung
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Requirement for LIml in head-organizer function

William Shawlot
Richard R. Behringer
Research30 Mar 1995
Nature

Volume: 374, P: 425-430
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma

O Arrieta
P Guevara
J Sotelo
ResearchOpen Access22 Mar 2005
British Journal of Cancer

Volume: 92, P: 1247-1252

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