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Showing 201–250 of 406 results

Advanced filters: Author: R Rowley Clear advanced filters

Ten novel 11q23 chromosomal partner sites

CJ Harrison
A Cuneo
LM Secker-Walker
News29 May 1998
Leukemia

Volume: 12, P: 811-822
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

MCL1 — essential for the survival of stem and progenitor cells of multiple lineages — is unique among pro-survival BCL2 family members in that it is rapidly turned over through the action of ubiquitin ligases. Abnormally high levels of MCL1 are expressed in some cancers, but the mechanism of MCL1 overexpression is not well understood. The deubiquitinase USP9X is now shown to stabilize MCL1 and thereby promote cell survival; this makes it a potential therapeutic target.

Martin Schwickart
XiaoDong Huang
Vishva M. Dixit
Research20 Dec 2009
Nature

Volume: 463, P: 103-107
Anaphylaxis during autologous peripheral blood progenitor cell infusion

DM Essayan
R Schilder
ED King
Research01 Apr 1997
Bone Marrow Transplantation

Volume: 19, P: 749-752
ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

The cytoskeleton plays a key role in cell/cell junction formation, but how the coordinated behaviour of the cytoskeleton contributes is not known. Here the authors show that actin-microtubule crosslinker ACF7 plays a key role in tight junction stabilization and wound healing in intestinal epithelium.

Yanlei Ma
Jiping Yue
Xiaoyang Wu
ResearchOpen Access25 May 2017
Nature Communications

Volume: 8, P: 1-16
Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

Tania Rowley et al. present multivalent Fc molecules with enhanced avidity for Fc gamma receptors in order to improve the treatment of autoantibody-mediated human diseases. They found several key amino acids involved in Fc receptor binding interactions.

Tania F. Rowley
Shirley J. Peters
David P. Humphreys
ResearchOpen Access14 Sept 2018
Communications Biology

Volume: 1, P: 1-12
A randomized study of multi-day infusion of autologous peripheral blood progenitor cells

H Abdel-Razeq
B Pohlman
B Bolwell
Research05 Mar 1998
Bone Marrow Transplantation

Volume: 21, P: 221-223
Highly structured homolog pairing reflects functional organization of the Drosophila genome

Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.

Jumana AlHaj Abed
Jelena Erceg
C.-ting Wu
ResearchOpen Access03 Oct 2019
Nature Communications

Volume: 10, P: 1-14
Greenland ice sheet climate disequilibrium and committed sea-level rise

Greenland ice sheet melt is currently the largest single contributor to sea-level rise. This work combines observations and theory to show that Greenland ice sheet imbalance with recent climate (2000–2019) has already committed at least 3.3% ice volume loss, equivalent to 274 mm of global sea-level rise.

Jason E. Box
Alun Hubbard
Robert S. Fausto
ResearchOpen Access29 Aug 2022
Nature Climate Change

Volume: 12, P: 808-813
The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos

Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.

Jelena Erceg
Jumana AlHaj Abed
C.-ting Wu
ResearchOpen Access03 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Predicting conversion to wet age-related macular degeneration using deep learning

In individuals diagnosed with age-related macular degeneration in one eye, a deep learning model can predict progression to the ‘wet’, sight-threatening form of the disease in the second eye within a 6-month time frame.

Jason Yim
Reena Chopra
Jeffrey De Fauw
Research18 May 2020
Nature Medicine

Volume: 26, P: 892-899
Human and mouse essentiality screens as a resource for disease gene discovery

Discovery of causal variants for monogenic disorders has been facilitated by whole exome and genome sequencing, but does not provide a diagnosis for all patients. Here, the authors propose a Full Spectrum of Intolerance to Loss-of-Function (FUSIL) categorization that integrates gene essentiality information to aid disease gene discovery.

Pilar Cacheiro
Violeta Muñoz-Fuentes
Coleen Kane
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation

MG Rizzo
A Zepparoni
A Sacchi
Research01 May 1998
British Journal of Cancer

Volume: 77, P: 1429-1438
The prognostic significance of allelic imbalance at key chromosomal loci in oral cancer

M Partridge
G Emilion
J Langdon
ResearchOpen Access12 Mar 1999
British Journal of Cancer

Volume: 79, P: 1821-1827
Phase separation drives aberrant chromatin looping and cancer development

The NUP98–HOXA9 oncogenic fusion protein found in leukaemia undergoes phase separation in the nucleus, which helps to promote activation of leukaemic genes and to establish aberrant chromatin looping.

Jeong Hyun Ahn
Eric S. Davis
Gang Greg Wang
Research23 Jun 2021
Nature

Volume: 595, P: 591-595
Mobilization of peripheral blood stem cells with docetaxel and cyclophosphamide (CY) in patients with metastatic breast cancer: a randomized trial of 3 vs 4 g/m² of CY

C H Weaver
L S Schwartzberg
C D Buckner
Research26 Feb 1999
Bone Marrow Transplantation

Volume: 23, P: 421-425
High-dose cytosine arabinoside plus etoposide as initial treatment for acute myeloid leukaemia: a single centre study

P Parikh
R Powles
M Hewetson
Research01 Nov 1990
British Journal of Cancer

Volume: 62, P: 830-833
Comparison of marrow vs blood-derived stem cells for autografting in previously untreated multiple myeloma

N Raje
R Powles
J Treleaven
Research01 Jun 1997
British Journal of Cancer

Volume: 75, P: 1684-1689
Breaking the rules of cancer

A cancer genetics dogma states that hematologic malignancies arise as a result of defined chromosomal translocations, whereas mutations underlie epithelial solid tumors. This rule is now broken in an analysis of chromosomal translocations in prostate cancer.

David R Shaffer
Pier Paolo Pandolfi
News & Views01 Jan 2006
Nature Medicine

Volume: 12, P: 14-15
Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival

P R Twentyman
Research01 Aug 1980
British Journal of Cancer

Volume: 42, P: 297-304
Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations

M Busson-Le Coniat
F Salomon-Nguyen
R Berger
Research02 Dec 1999
Leukemia

Volume: 13, P: 1975-1981
JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia

E Duprez
J-H Tong
M Lanotte
Research03 Apr 1997
Oncogene

Volume: 14, P: 1563-1570
CARRIER FREQUENCIES FOR SANDHOFF DISEASE (SHD) AND TAY-SACHS (TSD) IN AMERICAN JEWISH (J) AND NON-JEWISH (NJ) POPULATIONS

R Cantor
J Lim
M Kaback
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 220
DEFECTIVE CHYLOMICRON REMNANT CLEARANCE IN PATIENTS WITH FAMILIAL DYSBETAL IPOPROTEINEMIA

Jean A Cortner
Paul M Coates
Dennis R Cryer
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 220
Author Correction: Ongoing declines for the world’s amphibians in the face of emerging threats

Jennifer A. Luedtke
Janice Chanson
Simon N. Stuart
Amendments and CorrectionsOpen Access01 Dec 2023
Nature

Volume: 625, P: E2
Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context

Ella R. Thompson
Kylie L. Gorringe
Ian G. Campbell
ResearchOpen Access12 Oct 2015
Scientific Reports

Volume: 5, P: 1-6
Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm

B Gérard
H Cavé
B Grandchamp
Research01 Feb 1997
Leukemia

Volume: 11, P: 228-232
Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space

How leukaemia cells invade the bone marrow by outcompeting haematopoietic cells is still unclear. Here, the authors used detailed cell number measurements in conjunction with a dual pulse labelling method to determine proliferation rates and followed the in vivo dynamics of AML disease progression.

O. Akinduro
T. S. Weber
C. Lo Celso
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-12
Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma

R Saso
S Kulkarni
T Powles
ResearchOpen Access06 Jun 2000
British Journal of Cancer

Volume: 83, P: 91-94
Linking microbiome and stress hormone responses in wild tropical treefrogs across continuous and fragmented forests

Short-term tracking of treefrogs in southern Brazil, alongside microbiome and stress hormone profiling, suggests that forest fragmentation impacts microbiome diversity and composition, and that these changes might be mediated by the host stress response.

Wesley J. Neely
Renato A. Martins
C. Guilherme Becker
ResearchOpen Access12 Dec 2023
Communications Biology

Volume: 6, P: 1-15
Hematopoietic cell transplantation using plasma and DMSO without HES, with non-programmed freezing by immersion in a methanol bath: results in 213 cases

F Hernández-Navarro
E Ojeda
B Martínez
Research12 Mar 1998
Bone Marrow Transplantation

Volume: 21, P: 511-517
What happens subsequently in AML when cytogenetic abnormalities persist at bone marrow harvest? Results of the 10th UK MRC AML Trial

D Grimwade
H Walker
A Goldstone
Research01 Jun 1997
Bone Marrow Transplantation

Volume: 19, P: 1117-1123
Transplantation of highly purified peripheral blood CD34⁺ cells from HLA-mismatched parental donors in 14 children: evaluation of early monitoring of engraftment

C Peters
S Matthes-Martin
H Gadner
Research02 Dec 1999
Leukemia

Volume: 13, P: 2070-2078
Issues in implementing prenatal screening for cystic fibrosis: Results of a working conference

James E Haddow
Linda A Bradley
David R Witt
Research01 May 1999
Genetics in Medicine

Volume: 1, P: 129-135
Pharmacogenetics of anticancer drugs in non-Hodgkin lymphomas

L Loni
M Del Tacca
R Danesi
ReviewsOpen Access13 Nov 2001
British Journal of Cancer

Volume: 85, P: 1425-1431
Fibroblast growth factor-2 mediates transforming growth factor-β action in prostate cancer reactive stroma

F Yang
D W Strand
D R Rowley
Research16 Jul 2007
Oncogene

Volume: 27, P: 450-459
Multiple-reaction monitoring (MRM) LC–MS/MS quantitation of venlafaxine and its O-desmethyl metabolite for a preclinical pharmacokinetic study in rabbits

Abdul Aala Fazli
Bala Krishna Panigrahy
Nisar Ahmad Khan
ResearchOpen Access04 Jun 2022
Scientific Reports

Volume: 12, P: 1-18
Mechanisms for oscillatory true polar wander

Stabilization of the Earth’s rotation axis by a combination of long-term excess ellipticity and elastic stresses in the broken lithosphere provides an explanation for oscillatory true polar wander events spanning the past few billion years of Earth history.

J. R. Creveling
J. X. Mitrovica
I. Matsuyama
Research07 Nov 2012
Nature

Volume: 491, P: 244-248
The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical study of 30 cases

M Martineau
R Berger
LM Secker-Walker
News29 May 1998
Leukemia

Volume: 12, P: 788-791
Germline BAP1 mutations predispose to malignant mesothelioma

Joseph Testa, Michele Carbone and colleagues report that germline mutations in BAP1 predispose to malignant mesothelioma and uveal melanoma. They further hypothesize that mesothelioma predominates in BAP1 mutation carriers following exposure to asbestos.

Joseph R Testa
Mitchell Cheung
Michele Carbone
Research28 Aug 2011
Nature Genetics

Volume: 43, P: 1022-1025
The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients

DM Lillington
BD Young
LM Secker-Walker
News29 May 1998
Leukemia

Volume: 12, P: 801-804
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer.

Alex R. D. Delbridge
Stephanie Grabow
David L. Vaux
Reviews29 Jan 2016
Nature Reviews Cancer

Volume: 16, P: 99-109
WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients

Di Liu
Chunyan Wu
Bo Su
ResearchOpen Access09 Jun 2015
Scientific Reports

Volume: 5, P: 1-14
The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice

Richard R Tamesis
Elisabeth M Messmer
C Stephen Foster
Research01 May 1994
Eye

Volume: 8, P: 298-306
High-dose carboplatin, etoposide and melphalan (CEM) with peripheral blood progenitor cell support as late intensification for high-risk cancer: non-haematological, haematological toxicities and role of growth factor administration

P Benedetti Panici
L Pierelli
S Mancuso
Research01 Apr 1997
British Journal of Cancer

Volume: 75, P: 1205-1212
Mutations in RECQL are not associated with breast cancer risk in an Australian population

Na Li
Simone M. Rowley
Ian G. Campbell
Correspondence17 Sept 2018
Nature Genetics

Volume: 50, P: 1346-1348
Assessment of candidate high-grade serous ovarian carcinoma predisposition genes through integrated germline and tumour sequencing

Deepak N. Subramanian
Maia Zethoven
Ian G. Campbell
ResearchOpen Access10 Jan 2025
npj Genomic Medicine

Volume: 10, P: 1-16
Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukemia following chemotherapy and allogeneic bone marrow transplantation

J Boer
H Mahmoud
R Krance
Research01 Feb 1997
Leukemia

Volume: 11, P: 299-300
Karyotype analysis of carcinogen-treated Chinese hamster cells in vitro evolving from a normal to a malignant phenotype

J R Connell
Research01 Aug 1984
British Journal of Cancer

Volume: 50, P: 167-177
Environmental fluctuations and host skin bacteria shift survival advantage between frogs and their fungal pathogen

Ana V Longo
Kelly R Zamudio
Research09 Dec 2016
The ISME Journal

Volume: 11, P: 349-361
Mutations in TRPV4 cause an inherited arthropathy of hands and feet

Shireen Lamandé and colleagues report mutations in TRPV4 in familial digital arthropathy-brachydactyly (FDAB), which is characterized by osteoarthropathy of the fingers and toes. TRPV4 is a cation channel, and functional experiments suggest mutant proteins are not localized properly to the cell surface.

Shireen R Lamandé
Yuan Yuan
John F Bateman
Research02 Oct 2011
Nature Genetics

Volume: 43, P: 1142-1146

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