Nature Search

Quantum-enhanced nanodiamond rapid test advances early SARS-CoV-2 antigen detection in clinical diagnostics

Spin-enhanced lateral flow tests use nanodiamonds for the sensitive, robust detection of disease biomarkers. Here, authors report a clinical evaluation of a test for SARS-CoV-2 antigen, finding 95.1% sensitivity (Ct ≤ 30) and 100% specificity, with detection 2.0 days earlier than conventional tests.

Alyssa Thomas DeCruz
Benjamin S. Miller
Rachel A. McKendry
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-13
The Panoptes system uses decoy cyclic nucleotides to defend against phage

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

Ashley E. Sullivan
Ali Nabhani
Benjamin R. Morehouse
ResearchOpen Access01 Oct 2025
Nature

P: 1-9
Detection of organic compounds in freshly ejected ice grains from Enceladus’s ocean

Fresh ice grains from Enceladus’s plume were analysed during the highest-speed fly-by of the Cassini spacecraft. Organic compounds with a range of chemical structures were discovered, suggesting comprehensive subsurface chemistry on Enceladus.

Nozair Khawaja
Frank Postberg
Ralf Srama
ResearchOpen Access01 Oct 2025
Nature Astronomy

P: 1-10
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1

This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

Sirikrishna Thatavarthy
Luciano A. Abriata
Halil Aydin
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-18
Correlates of risk of respiratory syncytial virus disease: a prospective cohort study

This study found higher RSV antibody levels were associated with lower RSV risk in children outside the hospital. An earlier rise in incidence and higher incidence rates were observed among children <5 years compared to older children and adults.

Collrane Frivold
Sarah N. Cox
Helen Y. Chu
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Direct observations of airflow separation over ocean surface waves

The authors use laser imaging techniques to capture wind dynamics over the ocean. The fine-scale structure of the airflow within the first centimeters above waves reveals the coexistence of different wind-wave coupling mechanisms.

Marc P. Buckley
Jochen Horstmann
Jeff R. Carpenter
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-8
Fractal growth of copper electrodeposits

R. M. Brady
R. C. Ball
Research17 May 1984
Nature

Volume: 309, P: 225-229
The mediating role of job burnout in the relationship between career plateau and turnover intention among nurses

Shaghyegh Arzani
Mohammad Amerzadeh
Rohollah Kalhor
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-10
Embryopathic Effects of 7,12-Dimethylbenz(a)anthracene and its Hydroxymethyl Derivatives in the Sprague–Dawley Rat

A. R. CURRIE
C. C. BIRD
P. SIMS
Research06 Jun 1970
Nature

Volume: 226, P: 911-914
Expanding forest research with terrestrial LiDAR technology

This Review highlights how terrestrial laser scanning is transforming forest research by enabling highly detailed 3D measurements of trees, supporting applications in forest ecology, carbon monitoring, and biodiversity assessment.

Eduardo Eiji Maeda
Benjamin Brede
Louise Terryn
ReviewsOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Early Pliocene Sediments and Fossils from the Northern Kenya Rift Valley

W. W. BISHOP
G. R. CHAPMAN
Research06 Jun 1970
Nature

Volume: 226, P: 914-918
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program

A report from the first 2,000 newborns enrolled in the Early Check program, which offered genome screening covering 198 genes associated with early-onset diseases, shows the feasibility and potential clinical utility of the approach, leading to 28 true positive results.

Heidi L. Cope
Elizabeth R. Jalazo
Holly L. Peay
ResearchOpen Access05 Sept 2025
Nature Medicine

P: 1-10
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

D J Porteous
P A Thomson
D H Blackwood
Editorial24 Jan 2014
Molecular Psychiatry

Volume: 19, P: 141-143
Apex of Solar Motion of Neutral Hydrogen Concentrations at Different Velocities

V. R. VENUGOPAL
Research03 Oct 1970
Nature

Volume: 228, P: 44-45
Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis

Current first-line treatments of pediatric UC maintain a 6-month remission in only half of the patients. Here, applying multi-omics on intestinal biopsies from treatment-naïve children, the authors show that relapse-prediction using separate omics data is outperformed by a robust machine learning approach combining microbiomes and epigenomes.

Maria Kulecka
Jill O’Sullivan
Marcus J. Claesson
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Circulating tumor cell (CTC) clusters are much more likely to produce viable metastasis than single CTCs. Here the authors find that the transmembrane protein Plexin-B2 (PLXNB2) mediates homotypic and heterotypic CTC cluster formation, driving lung metastasis in breast cancer mouse models.

Emma Schuster
Nurmaa K. Dashzeveg
Huiping Liu
ResearchOpen Access16 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Sex-stratified genome-wide association meta-analysis of major depressive disorder

Sex differences are well established in the prevalence and symptoms of depression. Here, the authors identify a novel X chromosome variant, greater genetic risk, and stronger links to metabolic traits in females, highlighting the importance of sex-aware approaches.

Jodi T. Thomas
Jackson G. Thorp
Brittany L. Mitchell
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Species-specific serine metabolism differentially controls natural killer cell functions

Li et al. characterize overlapping and divergent metabolic requirements of human and murine NK cells in response to activation, with a focus on serine metabolism

Joey H. Li
Qinyan Feng
Timothy E. O’Sullivan
Research14 Aug 2025
Nature Metabolism

Volume: 7, P: 1905-1923
Maturation of human cardiac organoids enables complex disease modeling and drug discovery

Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

Mark W. Pocock
Janice D. Reid
James E. Hudson
ResearchOpen Access25 Jun 2025
Nature Cardiovascular Research

Volume: 4, P: 821-840
Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

Mark D. Iafrati
Richard H. Karas
Michael E. Mendelsohn
Research01 May 1997
Nature Medicine

Volume: 3, P: 545-548
Ozone concentrations in South-East England during the summer of 1976

A. J. Apling
E. J. Sullivan
R. E. Waller
Research01 Oct 1977
Nature

Volume: 269, P: 569-573
A Role for Thiol and Disulphide Groups in Determining the Rheological Properties of Dough Made from Wheaten Flour

R. FRATER
F. J. R. HIRD
J. R. YATES
Research07 May 1960
Nature

Volume: 186, P: 451-454
Predicting Earth's lifespan

Andrei Lapenis
Michael R. Rampino
Research20 May 1993
Nature

Volume: 363, P: 218
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Rare variant contribution to the heritability of coronary artery disease

Whole genome sequences enable discovery of rare variants which may help to explain the heritability of common diseases. Here the authors find that ultra-rare variants explain ~50% of coronary artery disease (CAD) heritability and highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.

Ghislain Rocheleau
Shoa L. Clarke
Ron Do
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Reiteration frequency of the gene for tissue-specific histone H5 in the chicken genome

A. C. Scott
J. R. E. Wells
Research26 Feb 1976
Nature

Volume: 259, P: 635-638
Rapid inactivation of aerosolised influenza virus using low-concentration gaseous hypochlorous acid

Koki Narihata
Masaru Minamiguchi
Yoshihiro Sakoda
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
Detection of a radio emission at 3 kHz in the outer heliosphere

W. S. Kurth
D. A. Gurnett
R. L. Poynter
Research01 Nov 1984
Nature

Volume: 312, P: 27-31
Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

CAR-T cells have been found to be less effective as treatment for solid tumours. Here the authors, utilising B7H3 as an antigen, consider how changes in B7H3 binders lead to functional changes of CAR-T cells and differences in tumour outcomes in humanised mouse tumour models.

Marta Barisa
Henrike P. Muller
John Anderson
ResearchOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial

In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89%, supporting a new treatment option for this tumor type.

Kari L. Kendra
Shay L. Bellasea
Antoni Ribas
Research14 Aug 2025
Nature Medicine

P: 1-7
Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans

The sexually transmitted human parasite Trichomonas vaginalis belongs to a clade of host-switching trichomonads that parasitize mammals, birds, livestock, and pets. Here the authors describe a chromosome-scale genome for T. vaginalis and assemblies of other bird and mammal-infecting species, identifying gene functions implicated in the spillover of trichomonads from birds to humans.

Steven A. Sullivan
Jordan C. Orosco
Jane M. Carlton
ResearchOpen Access24 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Variation in wood density across South American tropical forests

Wood density is a key control on tree biomass, and understanding its spatial variation improves estimates of forest carbon stock. Sullivan et al. measure >900 forest plots to quantify wood density and produce high resolution maps of its variation across South American tropical forests.

Martin J. P. Sullivan
Oliver L. Phillips
Joeri A. Zwerts
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-12
International Co-operation in Space Research (I)

EDWARD R. DYER jun.
Research04 Aug 1962
Nature

Volume: 195, P: 420-423
Unequal Bilateral Sodium Excretion in Sheep with an Exteriorized Ureter

B. D. STACY
A. H. BROOK
Research05 Jan 1963
Nature

Volume: 197, P: 49-50
On The Dangers Of Aligning RNA Sequences Using “Conserved” Motifs

Roderic Page
ResearchOpen Access18 Sept 2007
Nature Precedings

P: 1
Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

The tumor suppressor RAD51C is mutated in ovarian cancers. Through variant analysis the authors identify a mutation cluster in the RAD51C Walker B region important for the repair of DNA double-strand breaks and replicative damage. By identifying Walker B separation-of-function alleles, they show that these activities can be uncoupled.

Hayley L. Rein
Yashpal Rawal
Kara A. Bernstein
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-13
A Virus Disease of Meloidogyne incognita incognita, the Southern Root Knot Nematode

J. R. LOEWENBERG
T. SULLIVAN
M. L. SCHUSTER
Research12 Dec 1959
Nature

Volume: 184, P: 1896
In-operando high-speed microscopy and thermometry of reaction propagation and sintering in a nanocomposite

Imaging highly exothermic reactions in high spatial and temporal resolution to understand their underlying reaction mechanisms is challenging. Here, the authors develop a high-speed microscopy/pyrometry imaging system to successfully observe reactive sintering in a nanothermite reaction in-operando.

Haiyang Wang
Dylan J. Kline
Michael R. Zachariah
ResearchOpen Access10 Jul 2019
Nature Communications

Volume: 10, P: 1-8
Human infections with highly pathogenic avian influenza A(H5N1) viruses in the United States from March 2024 to May 2025

In an updated report on 70 laboratory-confirmed highly pathogenic avian influenza A H5N1 cases in the USA between March 2024 and May 2025, the absence of human-to-human transmission to date was confirmed, with no known mutations of resistance to neuroaminidase inhibitors.

Melissa A. Rolfes
Krista Kniss
Sonja J. Olsen
Research25 Jul 2025
Nature Medicine

P: 1-10
Displacement Chromatography on Cation-Exchange Materials

J. R. BENDALL
S. M. PARTRIDGE
R. G. WESTALL
Research13 Sept 1947
Nature

Volume: 160, P: 374-375
Structural Requirements of Selective Inhibition of Enteroviruses by 2-(α-Hydroxybenzyl)-benzimidazole and Related Compounds

I. TAMM
H. J. EGGERS
K. FOLKERS
Research23 Aug 1969
Nature

Volume: 223, P: 785-788
Evidence of thermophilization in Afromontane forests

Thermophilization is a change in species community composition towards greater abundances of species associated with warmer environments. This study provides evidence of thermophilization in understudied Afromontane forests, but with drivers that are distinct from other forest types.

Aida Cuni-Sanchez
Emanuel H. Martin
Martin J. P. Sullivan
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-9
Synthesis of growth hormone by bacteria

P. H. Seeburg
J. Shine
H. M. Goodman
Research01 Dec 1978
Nature

Volume: 276, P: 795-798
Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos

David J. Sharp
Kristina R. Yu
Jonathan M. Scholey
Research01 May 1999
Nature Cell Biology

Volume: 1, P: 51-54
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

In this genomic analysis of peripheral blood samples of the phase 3 CheckMate-067 trial of ipilimumab (IPI) versus nivolumab (NIVO) versus ipilimumab and nivolumab (IPI-NIVO) in melanoma, the status of certain mitochondrial haplogroups in patients was associated therapeutic resistance to NIVO or IPI-NIVO, a finding validated in an independent cohort.

Kelsey R. Monson
Robert Ferguson
Tomas Kirchhoff
ResearchOpen Access05 Jun 2025
Nature Medicine

Volume: 31, P: 2385-2396
Vitamin B₁₂ and Protein Biosynthesis: Vitamin B₁₂ and Biosynthesis in Rat Liver

H. R. V. ARNSTEIN
J. L. SIMKIN
Research21 Feb 1959
Nature

Volume: 183, P: 523-525
Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype

The complexity of epithelial cell states in the fibrotic niche in the context of chronic kidney disease remains incompletely understood. Here the authors integrate snRNA and ATAC-seq with high-plex single-cell molecular imaging to generate a spatially-revolved multiomic atlas of human kidney disease.

Maximilian Reck
David P. Baird
Bryan R. Conway
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-23
Biogenic lipids in particulates from the lower atmosphere over the eastern Atlantic

Bernd R. T. Simoneit
R. Chester
G. Eglinton
Research01 Jun 1977
Nature

Volume: 267, P: 682-685
Molecular variants of human Ia-like antigens

R. L. IKEMAN
A. K. SULLIVAN
L. M. JERRY
Research16 Mar 1978
Nature

Volume: 272, P: 267-268

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