Using two gas chromatography columns and a mass spectrometer, comprehensive two-dimensional gas chromatography–mass spectrometry (GC×GC–MS) is a powerful tool for separating and analysing gas-phase compounds. This Primer provides an overview of GC×GC–MS, including experimental set-up, analysis and applications in food science, environmental studies, petrochemicals and various -omics fields.
- Luigi Mondello
- Chiara Cordero
- Peter Q. Tranchida
