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SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells

Glucagon production in pancreatic islet α cells requires the PC2 enzyme. Here, authors show SEL1L-HRD1 ERAD ensures proper maturation of PC2, highlighting an essential mechanism for maintaining glucagon production.

Wenzhen Zhu
Linxiu Pan
Rachel Byerley Reinert
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-16

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SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells

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