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Showing 1–7 of 7 results
Advanced filters: Author: Raghavan Murugan Clear advanced filters

  • Acute kidney injury (AKI) is common, especially in the critically ill, and is a serious condition associated with substantial morbidity and mortality. In this Review, Murugan and Kellum discuss the epidemiology and prognosis of critically ill patients with AKI as well as describe the role of AKI criteria, biomarkers and therapy on patient outcomes.

    • Raghavan Murugan
    • John A. Kellum
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 209-217

  • Pregnancy-associated acute kidney injury is a risk factor for maternal and fetal morbidity and mortality and a driver of health inequity worldwide. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations on the causes, diagnosis, management and follow-up of pregnancy-associated acute kidney injury.

    • Cathy Nelson-Piercy
    • Nattachai Srisawat
    • Marlies Ostermann
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 633-646

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • Rajasree Menon
    • Sanjay Jain
    ResearchOpen Access
    Nature
    Volume: 619, P: 585-594

  • Here, the authors describe the mechanisms of ultrafiltration during kidney replacement therapy, the effects of ultrafiltration on cardiovascular physiology and the principles of volume management in critically ill patients. They also discuss potential mechanisms that could underlie the association between ultrafiltration rate and organ dysfunction.

    • Raghavan Murugan
    • Rinaldo Bellomo
    • John A. Kellum
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 262-276