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Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy

A deep-learning method designs lipid nanoparticles that deliver mRNA to the ferret lung.

Jacob Witten
Idris Raji
Daniel G. Anderson
Research10 Dec 2024
Nature Biotechnology

P: 1-10
Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery

A high-throughput method leveraging peptide-encoding mRNA barcodes for the in vivo screening of libraries of nanoparticle formulations allows for the rapid optimization of a lipid nanoparticle for the delivery of mRNA to the liver.

Luke H. Rhym
Rajith S. Manan
Daniel G. Anderson
Research01 May 2023
Nature Biomedical Engineering

Volume: 7, P: 901-910
Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation

C–H activations and hydroaminations are useful synthetic procedures for building up complex, functional molecules. Here, the authors report a single catalyst capable of performing tandem C–H activation and hydroamination, giving access to N-heterocycles via the [4+2] annulation of aromatic imines and alkynes.

Rajith S. Manan
Pinjing Zhao
ResearchOpen Access20 Jun 2016
Nature Communications

Volume: 7, P: 1-11
Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

A high-throughput screen improves lipid nanoparticle delivery of gene editors in the lung.

Bowen Li
Rajith Singh Manan
Daniel Anderson
Research30 Mar 2023
Nature Biotechnology

Volume: 41, P: 1410-1415
Combinatorial development of nebulized mRNA delivery formulations for the lungs

Nebulized mRNA delivery has broad therapeutic potential but has proven challenging. Here, the authors report on a modified lipid nanoparticle with improved conditions to allow nebulization and demonstrate its application for delivering mRNA to the lungs.

Allen Y. Jiang
Jacob Witten
Daniel G. Anderson
Research20 Nov 2023
Nature Nanotechnology

Volume: 19, P: 364-375

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Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy

Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery

Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

Combinatorial development of nebulized mRNA delivery formulations for the lungs

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