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Showing 1–7 of 7 results
Advanced filters: Author: Ran Zalk Clear advanced filters

  • Using electron cryomicroscopy, the closed-state structure of rabbit RyR1 is determined at 4.8 Å resolution; analysis confirms that the RyR1 architecture consists of a six-transmembrane ion channel with a cytosolic α-solenoid scaffold, and suggests a mechanism for Ca2+-induced channel opening.

    • Ran Zalk
    • Oliver B. Clarke
    • Andrew R. Marks
    Research
    Nature
    Volume: 517, P: 44-49

  • Amyloid fibrils assembled by an alternating lysine/phenylalanine peptide exhibit remarkable catalytic properties for β-lactam antibiotic hydrolysis. Specifically, the fibrils adopt coiled-coil structure underscoring an allosteric catalytic mechanism.

    • Sisira Mambram Kunnath
    • Elad Arad
    • Raz Jelinek
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The archaellum, or archaeal ‘flagellum’, includes asparagine-linked glycans that are important for efficient cell motility in archaea through unclear mechanisms. Here, the authors show that glycan truncation leads to clustering of filaments and alterations in cell motility, suggesting that the glycans minimize archaellum filament aggregation that compromises cell motility.

    • Shahar Sofer
    • Zlata Vershinin
    • Iris Grossman-Haham
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Ferritin, the cellular iron storage complex, binds NCOA4 and is trafficked to the lysosome for degradation and iron release. Here, authors present the cryo-EM structure of the NCOA4-Ferritin complex with biophysical and cellular characterization.

    • Fabian Hoelzgen
    • Thuy T. P. Nguyen
    • Gabriel A. Frank
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Dysregulation of intracellular Ca2+ handling in cardiomyocytes occurs in heart failure and atrial fibrillation. In this Review, Marks and colleagues focus on diastolic Ca2+ leak from the sarcoplasmic reticulum via RYR2 as a feature and potential therapeutic target in both heart failure and atrial fibrillation.

    • Haikel Dridi
    • Alexander Kushnir
    • Andrew R. Marks
    Reviews
    Nature Reviews Cardiology
    Volume: 17, P: 732-747