A-kinase anchoring protein 1 (AKAP1) promotes the assembly of signalosomes on the mitochondrial outer membrane and act as a central hub for mitochondrial signalling. Here, the authors show that AKAP1 protects against MASLD progression by inhibiting mitochondrial GPAT1 activity and subsequent lysophosphatidic acid production.
- Linjie He
- Xiaojuan She
- Lele Ji
