Alpuche-Lazcano et al. produce virus-like particles (VLPs) by the sole expression of the full-length SARS-CoV-2 spike protein in Chinese Hamster Ovary (CHO) cells. Administration of adjuvanted VLPs to mice and hamsters induces the production of neutralizing antibodies, providing effective protection against SARS-CoV-2 infection.
- Sergio P. Alpuche-Lazcano
- Matthew Stuible
- Yves Durocher
