Regulatory T (Treg) cells have an important role in the maintenance of immune tolerance and continuously circulate in the body. During this migration, they engage in bidirectional crosstalk with lymphatic and blood endothelial cells, which regulates vascular permeability and determines Treg cell migration patterns and tissue residency. This Review examines the molecular mechanism of these interactions and how they could be targeted in the context of autoimmunity, transplantation and cancer.
- Wenji Piao
- Zachariah L. Lee
- Jonathan S. Bromberg