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Showing 1–12 of 12 results
Advanced filters: Author: Richard I. Gregory Clear advanced filters

  • The let-7 microRNA has been implicated in development and disease. Its expression must thus be tightly regulated, and previously uridylation and Lin28 were implicated in let-7 stability. Zcchc11 is now shown to be the uridylase that mediates pre–let-7 modification and regulates mature let-7 levels and activity in mouse embryonic stem cells.

    • John P Hagan
    • Elena Piskounova
    • Richard I Gregory
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 1021-1025

  • MicroRNAs offer the most efficient method yet devised for reprogramming somatic cells to pluripotent stem cells.

    • Hao-Ming Chang
    • Richard I Gregory
    News & Views
    Nature Biotechnology
    Volume: 29, P: 499-500

  • Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N6-methyladenosine (m6A) RNA modification in embryonic stem cells (ESCs). This m6A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.

    • Shuibin Lin
    • Richard I. Gregory
    News & Views
    Nature Cell Biology
    Volume: 16, P: 129-131

  • Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3′ untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.

    • Robinson Triboulet
    • Richard I. Gregory
    News & Views
    Nature Cell Biology
    Volume: 12, P: 928-929

  • The microRNA (miRNA) biogenesis pathway is frequently altered in cancer, leading to global downregulation of miRNA levels in some cancer types. This Review discusses the alterations that affect miRNA biogenesis in cancer.

    • Shuibin Lin
    • Richard I. Gregory
    Reviews
    Nature Reviews Cancer
    Volume: 15, P: 321-333

  • Embryonic stem cells have a shortened cell cycle that allows for rapid proliferation, but the exact mechanisms are unclear. Here, a microRNA target, Trim71, is shown to inhibit the expression of a cyclin-dependent kinase inhibitor, thus enabling the G1–S phase cell cycle transition in embryonic stem cells.

    • Hao-Ming Chang
    • Natalia J. Martinez
    • Richard I. Gregory
    Research
    Nature Communications
    Volume: 3, P: 1-10

  • MicroRNAs (miRNAs) can regulate gene expression is by preventing translation of a target mRNA.

    This is because a complex involved in processing miRNAs, RISC, associates with the 60S ribosome subunit and the eIF6 translation initiation factor. As the eIF6 can prevent the 60S subunit from assembling into a mature 80S ribosome, interaction of eIF6 with RISC may block ribosome recycling or initiation.

    • Thimmaiah P. Chendrimada
    • Kenneth J. Finn
    • Ramin Shiekhattar
    Research
    Nature
    Volume: 447, P: 823-828

  • This study shows that Dis3l2 is the 3′–5′ exonuclease that mediates the degradation of uridylated precursor let-7 microRNA; this is the first physiological RNA substrate identified for this new exonuclease, which causes the Perlman syndrome of fetal overgrowth and Wilms’ tumour susceptibility when mutated.

    • Hao-Ming Chang
    • Robinson Triboulet
    • Richard I. Gregory
    Research
    Nature
    Volume: 497, P: 244-248