Nature Search

Mice lacking both subunits of lysosomal β–hexosaminidase display gangliosidosis and mucopolysaccharidosis

Kazunori Sango
Michael P. McDonald
Richard L. Proia
Research01 Nov 1996
Nature Genetics

Volume: 14, P: 348-352
Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage

Hui Qi
Jerome Cole II
Nawajes Mandal
ResearchOpen Access23 May 2019
Scientific Reports

Volume: 9, P: 1-13
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

Kazunori Sango
Shoji Yamanaka
Richard L. Proia
Research01 Oct 1995
Nature Genetics

Volume: 11, P: 170-176
Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.

Jeffrey T. Kroetsch
Andrew S. Levy
Steffen-Sebastian Bolz
ResearchOpen Access05 Apr 2017
Nature Communications

Volume: 8, P: 1-14
Erratum: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Masaru Ishii
Jackson G. Egen
Ronald N. Germain
Amendments and Corrections17 Jun 2010
Nature

Volume: 465, P: 966
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Mehrdad Matloubian
Charles G. Lo
Jason G. Cyster
Research22 Jan 2004
Nature

Volume: 427, P: 355-360
Gangliosides help stabilize the brain

Defects in the breakdown of gangliosides are associated with a class of disorders known as lysosomal storage diseases. Now, a defect in the synthesis of gangliosides, glycolipids that contain sialic acid and are abundant in the brain, has been shown to underlie an inherited form of epilepsy.

Richard L Proia
News & Views01 Nov 2004
Nature Genetics

Volume: 36, P: 1147-1148
Bioluminescence imaging of G protein-coupled receptor activation in living mice

G protein-coupled receptors are involved in numerous physiological functions, thus, they represent potential pharmaceutical targets. Here Kono et al. describe a new mouse model to image GPCR activation in real-time by exploiting firefly split luciferase fragment complementation that can be detected by bioluminescence imaging.

Mari Kono
Elizabeth G. Conlon
Richard L. Proia
ResearchOpen Access27 Oct 2017
Nature Communications

Volume: 8, P: 1-11
The receptor S1P₁ overrides regulatory T cell–mediated immune suppression through Akt-mTOR

Regulatory T cells (T_reg cells) are necessary for maintaining peripheral tolerance. Chi and colleagues show that the receptor S1P₁ negatively regulates thymic T_reg cell production and blocks T_reg cell activity via an Akt-mTor pathway.

Guangwei Liu
Samir Burns
Hongbo Chi
Research31 May 2009
Nature Immunology

Volume: 10, P: 769-777
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone

Guy Cinamon
Mehrdad Matloubian
Jason G Cyster
Research06 Jun 2004
Nature Immunology

Volume: 5, P: 713-720
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

The environmental cues involved in regulating germinal center size are not fully understood. Cyster and colleagues show that the sphingosine 1-phosphate receptor S1P₂ controls the survival and localization of B cells in germinal centers by antagonizing signaling by the kinase Akt and follicular chemoattractants.

Jesse A Green
Kazuhiro Suzuki
Jason G Cyster
Research05 Jun 2011
Nature Immunology

Volume: 12, P: 672-680
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Nathan Pankratz, Santhi Ganesh and colleagues use exome chip data to identify rare and common variants influencing blood cell traits. They report associations at several loci, including a rare missense variant in S1PR4 associated with circulating neutrophil counts, and present functional studies supporting a role for S1PR4 in neutrophil recruitment and resolution in response to tissue injury.

Nathan Pankratz
Ursula M Schick
Santhi K Ganesh
Research11 Jul 2016
Nature Genetics

Volume: 48, P: 867-876
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

Physiological Stat3 signaling is temporally restricted. In cancer, Stat3 activity is often persistently elevated and fosters progression through its effects on tumor cells and their microenvironment. This report identifies the reciprocal positive regulation of S1PR1 and Stat3 in tumors as a mechanism by which tumor cells and their environment crosstalk to maintain Stat3 activity. This persistent loop is required for tumor progression and metastasis and could be a potential therapeutic target to block oncogenic Stat3 signaling.

Heehyoung Lee
Jiehui Deng
Hua Yu
Research21 Nov 2010
Nature Medicine

Volume: 16, P: 1421-1428
The alliance of sphingosine-1-phosphate and its receptors in immunity

Recent research has shown that the interaction of sphingosine-1-phosphate with its receptors (S1PR1–S1PR5) has an essential role in regulating immune responses, not only through the control of immune-cell trafficking but also through effects on immune-cell function. Understanding these effects holds promise for the use of S1PR ligands as immunomodulatory therapeutics.

Juan Rivera
Richard L. Proia
Ana Olivera
Reviews01 Oct 2008
Nature Reviews Immunology

Volume: 8, P: 753-763
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

Apolipoprotein-M-bound sphingosine-1-phosphate (S1P) is found to restrain the generation of new lymphocytes—and, consequently, adaptive immune responses—by activating the S1P₁ receptor on bone marrow lymphocyte progenitors in mice.

Victoria A. Blaho
Sylvain Galvani
Timothy Hla
Research08 Jun 2015
Nature

Volume: 523, P: 342-346
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Osteoclasts resorb bone and their precursor cells express sphingosine-1-phosphate (S1P) receptors. Too much S1P, and too many osteoclast precursors move into the blood; too little S1P results in increased attachment to bone and osteoporosis. Furthermore, S1P receptor stimulation in live mice diminishes bone loss in a mouse model of postmenopausal osteoporosis.

Masaru Ishii
Jackson G. Egen
Ronald N. Germain
Research08 Feb 2009
Nature

Volume: 458, P: 524-528
Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation

Kazuhiro Ishimaru
Kazuaki Yoshioka
Yoh Takuwa
ResearchOpen Access04 Dec 2019
Scientific Reports

Volume: 9, P: 1-14

Search

Mice lacking both subunits of lysosomal β–hexosaminidase display gangliosidosis and mucopolysaccharidosis

Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage

Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

Erratum: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Gangliosides help stabilize the brain

Bioluminescence imaging of G protein-coupled receptor activation in living mice

The receptor S1P₁ overrides regulatory T cell–mediated immune suppression through Akt-mTOR

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone

The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

The alliance of sphingosine-1-phosphate and its receptors in immunity

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation

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