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Showing 1–12 of 12 results
Advanced filters: Author: Richard P. Bendall Clear advanced filters

    • Dick van der Wateren
    • Richard Hindmarsh
    News & Views
    Nature
    Volume: 376, P: 389-391

  • Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

    • Peter Sandercock
    • Janet Darbyshire
    • Martin J. Landray
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • The work of Michael Angelo and colleagues uses multiplexed ion beam imaging (MIBI) to localize and visualize protein expression in a manner analogous to immunohistochemistry (IHC) while circumventing some of the limitations of conventional IHC with clinical samples. MIBI uses secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters, expanding the number of targets that can be analyzed simultaneously to about 100. The approach, used here to image breast tumor tissue sections, offers over a five-log dynamic range and compatibility with standard formalin-fixed, paraffin-embedded tissue sections.

    • Michael Angelo
    • Sean C Bendall
    • Garry P Nolan
    Research
    Nature Medicine
    Volume: 20, P: 436-442

  • The differentiation of αβ T cells is a complex process. Using data sets from the Immunological Genome Project, Benoist and colleagues identify candidate mediators of key transitions during thymocyte selection and maturation.

    • Michael Mingueneau
    • Taras Kreslavsky
    • Shannon Turley
    Research
    Nature Immunology
    Volume: 14, P: 619-632

  • Hepatitis E virus (HEV) is the causative agent of hepatitis E, and extrahepatic manifestations, including various types of neurological injury, have also been reported in individuals with HEV infection. The most common neurological manifestations are Guillain–Barré syndrome (GBS), neuralgic amyotrophy, and encephalitis and/or myelitis. In this article, the authors review the reported cases of HEV-associated neurological injury, discuss the possible pathogenic mechanisms, and outline future directions and research questions.

    • Harry R. Dalton
    • Nassim Kamar
    • Bart C. Jacobs
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 77-85

  • The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

    • Sanjay Jain
    • Liming Pei
    • Michael P. Snyder
    Reviews
    Nature Cell Biology
    Volume: 25, P: 1089-1100

  • A multilaboratory analysis characterized the ability of 27 different labs to identify 20 proteins at equimolar concentrations in a highly purified test sample mixture using mass spectrometry. The results show that while the technology is reproducible, many common experimental problems arise, and improved search engines and databases are still needed.

    • Alexander W Bell
    • Eric W Deutsch
    • Juan Antonio Vizcaíno
    Research
    Nature Methods
    Volume: 6, P: 423-430