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BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication

Monomethylation of histone H4 lysine 20 (H4K20me1) contributes to DNA replication but the mechanism is not well understood. Here, the authors identify a conserved tandem Tudor domain of BAHCC1 as a H4K20me1-specific reader, which promotes the recruitment of MCM complex to chromatin for efficient DNA replication.

Dongxu Li
Zhi-Min Zhang
Gang Greg Wang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Erratum

Agnieszka Gambus
Richard C. Jones
Karim Labib
Amendments and Corrections12 Mar 2006
Nature Cell Biology

Volume: 8, P: 424
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons

Trinucleotide-repeat-containing 18 (TNRC18), which has poorly understood functions, is now identified as an H3K9me3-specific reader that silences endogenous retroviruses.

Shuai Zhao
Jiuwei Lu
Gang Greg Wang
Research08 Nov 2023
Nature

Volume: 623, P: 633-642
Phase separation drives aberrant chromatin looping and cancer development

The NUP98–HOXA9 oncogenic fusion protein found in leukaemia undergoes phase separation in the nucleus, which helps to promote activation of leukaemic genes and to establish aberrant chromatin looping.

Jeong Hyun Ahn
Eric S. Davis
Gang Greg Wang
Research23 Jun 2021
Nature

Volume: 595, P: 591-595
Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast

Alberto Sanchez-Diaz
Vanessa Marchesi
Karim Labib
Research16 Mar 2008
Nature Cell Biology

Volume: 10, P: 395-406
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.

Jie Li
Phillip M. Galbo Jr.
Gang Greg Wang
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-18
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

Agnieszka Gambus
Richard C. Jones
Karim Labib
Research12 Mar 2006
Nature Cell Biology

Volume: 8, P: 358-366
An Investigation of the Behavior of Solvent based Polycaprolactone ink for Material Jetting

Yinfeng He
Ricky D. Wildman
Steven Edmondson
ResearchOpen Access12 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
SUMOylation of the GTPase Rac1 is required for optimal cell migration

The SUMO E3 ligase PIAS3 is shown to promote Rac1 SUMOylation. This modification stimulates Rac1 activity and regulates its ability to drive lamellipodium formation.

Sonia Castillo-Lluva
Michael H. Tatham
Angeliki Malliri
Research10 Oct 2010
Nature Cell Biology

Volume: 12, P: 1078-1085
Indicators of responsiveness to immune checkpoint inhibitors

Bradley D. Shields
Fade Mahmoud
Alan J. Tackett
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-12

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