Nature Search

Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci

Mignogna et al. analysed item nonresponse behaviour across 109 questionnaire items from 360,628 individuals in the UK Biobank using phenotypic and genetic data. This can inform our understanding of how item nonresponse might lead to bias in genetic studies more generally.

Gianmarco Mignogna
Caitlin E. Carey
Andrea Ganna
ResearchOpen Access29 Jun 2023
Nature Human Behaviour

Volume: 7, P: 1371-1387
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Richard Karlsson Linnér
Pietro Biroli
Jonathan P. Beauchamp
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 245-257
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Gene discovery and polygenic predictions from a genome-wide association study of educational attainment in 1.1 million individuals.

James J. Lee
Robbee Wedow
David Cesarini
Research23 Jul 2018
Nature Genetics

Volume: 50, P: 1112-1121
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Association studies of up to 1.2 million individuals identify 566 genetic variants in 406 loci associated with tobacco use and addiction (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci showing pleiotropic association.

Mengzhen Liu
Yu Jiang
Scott Vrieze
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 237-244
Publisher Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG

Patrick Turley
Raymond K. Walters
Daniel J. Benjamin
Amendments and Corrections30 May 2019
Nature Genetics

Volume: 51, P: 1190
Author Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG

Patrick Turley
Raymond K. Walters
Daniel J. Benjamin
Amendments and Corrections25 Jun 2019
Nature Genetics

Volume: 51, P: 1295
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation

Carey and colleagues reveal 35 major latent constructs (factors) in the phenotype data of unrelated individuals with predominantly estimated European genetic ancestry from UK Biobank.

Caitlin E. Carey
Rebecca Shafee
Elise B. Robinson
ResearchOpen Access04 Jul 2024
Nature Human Behaviour

Volume: 8, P: 1599-1615
Multi-trait analysis of genome-wide association summary statistics using MTAG

MTAG is a new method for joint analysis of summary statistics from genome-wide association studies of different traits. Applying MTAG to summary statistics for depressive symptoms, neuroticism and subjective well-being increased discovery of associated loci as compared to single-trait analyses.

Patrick Turley
Raymond K. Walters
Daniel J. Benjamin
Research01 Jan 2018
Nature Genetics

Volume: 50, P: 229-237
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Using a sample of more than 1 million individuals, Hatoum et al. identify genomic loci associated with general and substance-specific addiction risk.

Alexander S. Hatoum
Sarah M. C. Colbert
Arpana Agrawal
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 210-223
Model-based assessment of replicability for genome-wide association meta-analysis

In genome-wide association meta-analysis, it is often difficult to find an independent dataset of sufficient size to replicate associations. Here, the authors have developed MAMBA to calculate the probability of replicability based on consistency between datasets within the meta-analysis.

Daniel McGuire
Yu Jiang
Dajiang J. Liu
ResearchOpen Access30 Mar 2021
Nature Communications

Volume: 12, P: 1-14

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