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Showing 1–50 of 121 results

Advanced filters: Author: Robert A Copeland Clear advanced filters

Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Research17 Sept 2025
Nature Genetics

Volume: 57, P: 2427-2435
A comprehensive genetic map of the mouse genome

William F. Dietrich
Joyce Miller
Eric S. Lander
Research14 Mar 1996
Nature

Volume: 380, P: 149-152
A genetic map of the mouse with 4,006 simple sequence length polymorphisms

William F. Dietrich
Joyce C. Miller
Eric S. Lander
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 220-245
Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry

Kay E. Davies
Bryan D. Young
Robert Williamson
Research01 Oct 1981
Nature

Volume: 293, P: 374-376
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Amendments and Corrections29 Sept 2025
Nature Genetics

Volume: 57, P: 2604
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein

William G. Rice
Jim A. Turpin
Edward A. Sausville
Research01 Mar 1997
Nature Medicine

Volume: 3, P: 341-345
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33–q35

Afif Hentati
Khemissa Bejaoui
Teepu Siddique
Research01 Jul 1994
Nature Genetics

Volume: 7, P: 425-428
Initiating boiling with ice

ROBERT E. APFEL
RICHARD L. DAY
Research12 Jun 1986
Nature

Volume: 321, P: 657
Air Temperature during the Solar Eclipse

HUGH ROBERT MILL
Research27 Aug 1896
Nature

Volume: 54, P: 391
Galactic strings are stable

Robert Walgate
News & Views03 Jul 1986
Nature

Volume: 322, P: 17
Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

Wade H. Berrettini
Thomas N. Ferraro
Wolfgang H. Vogel
Research01 May 1994
Nature Genetics

Volume: 7, P: 54-58
Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial

Combination of immune checkpoint inhibitors with chemoradiation is now standard of care for patients with locally advanced cervical cancer (LACC). Here, the authors report the results of a phase I trial of neoadjuvant vs concurrent atezolizumab (anti-PD-L1) with chemoradiation for LACC.

Jyoti Mayadev
Dmitriy Zamarin
Russell J. Schilder
ResearchOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Origin of Plastids and the Phylogeny of Algae

ROBERT EDWARD LEE
Research05 May 1972
Nature

Volume: 237, P: 44-46
Tissue ablation by a free-electron laser tuned to the amide II band

Glenn Edwards
Regan Logan
Denis O'Day
Research29 Sept 1994
Nature

Volume: 371, P: 416-419
The Cause of an Ice Age

ROBERT S. BALL
Research18 Feb 1892
Nature

Volume: 45, P: 365
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

Here the authors discover a small-molecule that inhibits DNA polymerase theta by trapping the enzyme on DNA in the closed conformation. The inhibitor selectively kills BRCA-mutant cells and exhibits strong synergistic activity with PARP inhibitors.

William Fried
Mrityunjay Tyagi
Richard T. Pomerantz
ResearchOpen Access05 Apr 2024
Nature Communications

Volume: 15, P: 1-15
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Thorsten Heinzel
Robert M. Lavinsky
Michael G. Rosenfeld
Research01 May 1997
Nature

Volume: 387, P: 43-48
Correction: A comprehensive genetic map of the mouse genome

William F. Dietrich
Joyce Miller
Eric S. Lander
Amendments and Corrections09 May 1996
Nature

Volume: 381, P: 172
New targets in triple-negative breast cancer

In this Journal Club, Robert L. Copeland and Yasmine Kanaan discuss a paper that reports how ERβ and IGF2 signalling may contribute to the heterogeneity of triple-negative breast cancer observed in patients with different ancestries in the USA.

Robert L. Copeland
Yasmine Kanaan
Research Highlights07 Oct 2021
Nature Reviews Cancer

Volume: 21, P: 744
Stability of Hydrogen Compounds on Venus

ROBERT F. MUELLER
Research08 Aug 1964
Nature

Volume: 203, P: 625-626
Identification of the murine beige gene by YAC complementation and positional cloning

Charles M. Perou
Karen J. Moore
Jerry Kaplan
Research01 Jul 1996
Nature Genetics

Volume: 13, P: 303-308
Male and female mouse DNAs can be discriminated using retroviral probes

Sandra J. Phillips
Edward H. Birkenmeier
Evan M. Eicher
Research20 May 1982
Nature

Volume: 297, P: 241-243
Complete nucleotide sequence of the AIDS virus, HTLV-III

Lee Ratner
William Haseltine
Flossie Wong-Staal
Research24 Jan 1985
Nature

Volume: 313, P: 277-284
An African primate lentivirus (SIV_smclosely related to HIV-2

Vanessa M. Hirsch
Robert A. Olmsted
Philip R. Johnson
Research01 Jun 1989
Nature

Volume: 339, P: 389-392
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

James A. Johnston
Masaru Kawamura
John J. O'Shea
Research14 Jul 1994
Nature

Volume: 370, P: 151-153
Trophic position of Otodus megalodon and great white sharks through time revealed by zinc isotopes

Here the authors demonstrate the use of zinc isotopes (δ⁶⁶Zn) to geochemically assess trophic levels in extant and extinct sharks. They show that the Neogene megatooth shark (Otodus megalodon) and the great white shark (Carcharodon carcharias) occupied a similar trophic level.

Jeremy McCormack
Michael L. Griffiths
Thomas Tütken
ResearchOpen Access31 May 2022
Nature Communications

Volume: 13, P: 1-10
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land
Luis F. Parada
Robert A. Weinberg
Research18 Aug 1983
Nature

Volume: 304, P: 596-602
The link between vitamin D and prostate cancer

In this Journal Club, Kanaan and Copeland discuss a study showing that a high 1,25(OH)₂D:25(OH)D molar ratio, indicative of vitamin D metabolism, is inversely related to the risk of highly aggressive prostate cancer in African American men.

Yasmine Kanaan
Robert L. Copeland
Research Highlights27 Jun 2022
Nature Reviews Cancer

Volume: 22, P: 435
Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour

Finn Skou Pedersen
Robert L. Crowther
William A. Haseltine
Research09 Jul 1981
Nature

Volume: 292, P: 167-170
Loss of a Harvey ras allele in sporadic Wilms' tumour

Anthony E. Reeve
Philip J. Housiaux
Lynn J. Millow
Research10 May 1984
Nature

Volume: 309, P: 174-176
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

D. Simon
H. Stuhlmann
R. Jaenisch
Research21 Jul 1983
Nature

Volume: 304, P: 275-277
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

Baohua Huang
Matthias Eberstadt
Stephen W. Fesik
Research26 Dec 1996
Nature

Volume: 384, P: 638-641
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

Ding Xue
H. Robert Horvitz
Research21 Sept 1995
Nature

Volume: 377, P: 248-251
Image-based honey bee larval viral and bacterial diagnosis using machine learning

Duan C. Copeland
Brendon M. Mott
Kirk E. Anderson
ResearchOpen Access21 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Correction: Corrigendum: The promise and peril of chemical probes

Cheryl H Arrowsmith
James E Audia
William J Zuercher
Amendments and Corrections20 Oct 2015
Nature Chemical Biology

Volume: 11, P: 887
Conveying tactile object characteristics through customized intracortical microstimulation of the human somatosensory cortex

In this study, three individuals with tetraplegia designed vivid, reliable and object-appropriate sensations with a variety of tactile characteristics using self-selected stimulus parameters that stimulated their somatosensory cortex upon digital object contact

Ceci Verbaarschot
Vahagn Karapetyan
Robert A. Gaunt
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-17
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Wei Fan
Bruce A. Boston
Roger D. Cone
Research09 Jan 1997
Nature

Volume: 385, P: 165-168
Correction: Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

Robert M Bowers
Nikos C Kyrpides
Tanja Woyke
Amendments and Corrections06 Feb 2018
Nature Biotechnology

Volume: 36, P: 196
Correction: Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

Robert M Bowers
Nikos C Kyrpides
Tanja Woyke
Amendments and Corrections06 Jul 2018
Nature Biotechnology

Volume: 36, P: 660
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota l-carnitine catabolism

The gbu gene cluster, present in the human gut microbiota member Emergencia timonensis, converts γ-butyrobetaine (γBB) to trimethylamine in the conversion of dietary l-carnitine, which is found in red meat, to the proatherosclerotic metabolite trimethylamine-N-oxide. Individuals with high plasma γBB levels had increased risk of cardiovascular events.

Jennifer A. Buffa
Kymberleigh A. Romano
Stanley L. Hazen
Research23 Dec 2021
Nature Microbiology

Volume: 7, P: 73-86
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

Andrew V. Biankin
Nicola Waddell
Sean M. Grimmond
Research24 Oct 2012
Nature

Volume: 491, P: 399-405
A longitudinal study of queen health in honey bees reveals tissue specific response to seasonal changes and pathogen pressure

Duan C. Copeland
Vincent A. Ricigliano
Kirk E. Anderson
ResearchOpen Access18 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
fNIRS reproducibility varies with data quality, analysis pipelines, and researcher experience

FRESH, a multi-lab collaboration, reveals how data quality, analysis pipelines, and researcher expertise influence reproducibility in fNIRS neuroimaging, highlighting key factors driving variability in hypothesis outcomes.

Meryem A. Yücel
Robert Luke
Vit Zemanek
ResearchOpen Access04 Aug 2025
Communications Biology

Volume: 8, P: 1-17
Erratum: Drug–target residence time and its implications for lead optimization

Robert A. Copeland
David L. Pompliano
Thomas D. Meek
Amendments and Corrections01 Mar 2007
Nature Reviews Drug Discovery

Volume: 6, P: 252
Drug–target residence time and its implications for lead optimization

Pharmacological activity depends on the binding of drugs to their targets. Copelandet al. provide a perspective on the importance of residence time for lead optimization and describe the potential advantages of drugs with a long residence time, in terms of duration of pharmacological effects and selectivity.

Robert A. Copeland
David L. Pompliano
Thomas D. Meek
Reviews04 Aug 2006
Nature Reviews Drug Discovery

Volume: 5, P: 730-739
Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software

The Critical Assessment of Metagenome Interpretation (CAMI) community initiative presents results from its first challenge, a rigorous benchmarking of software for metagenome assembly, binning and taxonomic profiling.

Alexander Sczyrba
Peter Hofmann
Alice C McHardy
ResearchOpen Access02 Oct 2017
Nature Methods

Volume: 14, P: 1063-1071
Antibiotic treatment of honey bee colonies alters early gut microbiome assembly and induces persistent dysbiosis in newly emerged workers

Nathan O. Allen
Duan C. Copeland
Kirk E. Anderson
ResearchOpen Access08 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
The drug–target residence time model: a 10-year retrospective

Over the past decade, the drug–target residence time model has been broadly applied to drug discovery programmes across multiple therapeutic areas. To mark the 10 year anniversary of this model, Copeland discusses the benefits of assessing residence time, highlighting some of the advances in its theory and application.

Robert A. Copeland
Reviews18 Dec 2015
Nature Reviews Drug Discovery

Volume: 15, P: 87-95
Characterization of novel USP6 gene rearrangements in a subset of so-called cellular fibroma of tendon sheath

Jose G. Mantilla
John M. Gross
Robert W. Ricciotti
Research13 Jul 2020
Modern Pathology

Volume: 34, P: 13-19

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