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A noise-resilient protocol implemented in a cavity resonator coupled to a qubit demonstrates that large nonlinear couplings are not a necessary requirement for the fast universal control and state preparation of engineered quantum systems.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Cellular forces shaping cells and tissues during development are well understood, but their dynamic material properties less so. Here, the authors use Brillouin microscopy to map cell material properties in developing fruit fly embryos, revealing dynamic, fate-specific modulation.

An analysis of tree survival data from forest sites worldwide shows that in the tropics, rare tree species experience stronger stabilizing density dependence than common species, wheras no correlation of stabilizing density dependence and abundance exists in the temperate zone.

Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.

The authors combine biologically-inspired learning techniques with neuromorphic hardware to implement an energy-efficient system that demonstrates rapid learning of unseen tasks across various domains.

Multi-species occupancy modelling using camera-trap data from 725 sites across 20 North American cities shows how environmental and climate characteristics interact with species traits to influence the effects of urbanization on wildlife communities.

In wildlife tagging, stress from capture and handling can alter post- release behavior and potentially study interpretations. This study of 42 mammal species shows that these effects diminish within 4–7 days, and quicker for animals in high human activity areas indicating adaptation to disturbance.

Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.

Er³⁺ is implanted into CaWO₄, a material with non-polar site symmetry free of background rare earth ions, to realize reduced optical spectral diffusion in nanophotonic devices, representing a step towards making telecom band quantum repeater networks with single ions.

A modelling approach predicts SARS-CoV-2 variant dynamics on the basis of immunity and cross-neutralization, which was shaped by a region’s SARS-CoV-2 infection history.

Zhang et al. identify and characterize supermeres as extracellular nanoparticles that exhibit unique biological and functional properties with potential prognostic and therapeutic value across distinct diseases.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.

There are stable relationships between diet and microbiome in humans and lab animals. A study on African buffalo finds that diet influences microbiome variation and enterotype formation. Three pathogens may associate with microbiome depending on host diet, suggesting nutrition impacts relationships between gut microbiome and host health.

A scheme for watermarking the text generated by large language models shows high text quality preservation and detection accuracy and low latency, and is feasible in large-scale-production settings.

Manipulating the topological phases of quantum materials is necessary to fully leverage their potential for future electronics. Here, the authors experimentally demonstrate the controllable transition from a weak to a strong topological insulator phase through the in-situ application of high strain.

The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.

Animals form cognitive maps of the world to guide behavior. This study shows that the lateral orbitofrontal cortex is essential for creating precise, outcome-specific cognitive maps during initial learning, but not for general map creation in itself.

The true number of infections from SARS-Cov-2 is unknown and believed to exceed the reported numbers by several fold. National testing policies, in particular, can strongly affect the proportion of undetected cases. Here, the authors propose a method that reconstructs incidence profiles within minutes, solely from publicly available, time-stamped viral genomes.

Epigenetic information is transmitted from mother to daughter cells through mitosis. Here, the authors isolate native chromosomes from metaphase-arrested cells and perform LC-MS/MS to identify chromosome-bound proteins in pluripotent stem cells during mitosis and reveal that PRC2, DNA methylation and Mecp2 are required to maintain chromosome compaction.

The role of Ifi27l2a, an interferon-induced gene, remains poorly understood in diseased brains. Here, authors show age and stroke-dependent upregulation of Ifi27l2a in microglia, and that reduction of Ifi27l2a leads to reduced brain injury and functional deficits after ischemic stroke.

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions with the dynein light chain Tctex-1 and cortactin.

Pretrained on SpatialCorpus-110M, a curated resource of vast and diverse transcriptomes of dissociated and spatially resolved cells from both human and mouse, Nicheformer advances toward building foundation models for spatial single-cell analysis.

Dynamical patterns in nonequilibrium systems often stem from nonreciprocal interactions that violate Newton’s third law, posing challenges for theoretical analysis. By solving a model of active and passive particles, the study reveals how effective nonreciprocal couplings lead to dynamical phase behaviour that includes traveling interfaces, and a spinodal that protrudes beyond the binodal.

Classically ordered phases normally coupled directly to external probes but exotic multipolar phases are not straightforwardly accessible. Here the authors show that TmMgGaO₄ has multipolar order that can be inferred by inelastic neutron scattering and modeled by transverse field Ising model.

Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype data and identifies disease-associated genes with cell-type-specific effects.

Excitons can exhibit topologically non-trivial states. Here, the authors theoretically demonstrate that excitons can exhibit controllable topology and localization properties due to their geometry in organic polymers.

EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.

Rapid solvent flows stretch dissolved polymer chains to their breaking point by hitherto-elusive molecular mechanisms. Now, analysis of competing mechanochemical reactions suggests a broad distribution of molecular geometries of fracturing chains. This occurs because, in each chain, fracture and kinetically destabilizing backbone stretching compete on submillisecond timescales.

Epigenetic clocks estimate biological age and health risks. Here, the authors compare 14 clocks in 18,859 individuals, showing second-generation clocks better predict disease incidence and mortality, particularly for respiratory and liver-related conditions.

A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.

Although strategies to stabilize the singlet state of carbenes are known, obtaining stable triplet electromers remains a challenge. Now it has been shown that transition-metal substitution enables the generation of triplet metallocarbenes stabilized by spin-polarized push–pull interactions; these compounds exhibit appreciable lifetimes beyond cryogenic temperatures.

The inclusion of nuclear quantum effects (NQE) in atomistic simulations of chemical systems is of key importance. Here the authors use machine learned force fields trained on coupled cluster reference data to show the dynamical strengthening of covalent and non-covalent molecular interactions induced by NQE.

Electron-spin resonance spectroscopy can detect radical species in live cells, but the method suffers from limitations of spin-label stability and selectivity. Here, flavoproteins are employed as genetically encoded spin probes to reveal structural features of bacterial chemotaxis proteins in cell.

In metallic glasses, atomic-scale transport strongly affects the materials properties and thus performance in applications. Here the authors present the intermittent character of structural relaxation connected to microstructural heterogeneity, and power-law behavior at long time scales resulting from collective and correlated atomic motion.

Prefrontal cortex can be flexibly engaged in many different tasks. Yang et al. trained an artificial neural network to solve 20 cognitive tasks. Functionally specialized modules and compositional representations emerged in the network after training.

Using cryo-electron microscopy and integrative modeling, the authors defined the structure of vimentin intermediate filaments, revealing a helical tube built of five protofibrils that enclose a fiber of low-complexity N-terminal domains.

This study shows that the total energy loss of gravity currents has a non-linear dependence on the work required to keep sediment in suspension, highlighting the importance of large-scale mixing for the particulate transport of gravity currents.

During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.

In two independent studies, Song et al. and Jiang, Dalgarno et al. present computational frameworks, perturbation-response score and Mixscale, respectively, to determine individual cellular variation in response to perturbation.

Disentangling the various pathways by which climate change may drive community shifts in real-world ecosystems is challenging. Here the authors apply a trend attribution approach to a large dataset from the MASTIF database to assess the contribution of direct and indirect effects of climate on tree fecundity in North America, finding that the latter dominate trends by affecting tree growth and size and thereby fecundity.

Previous research shows surprising rewards drive learning. Here, the authors show that affective error signals (emotional surprise) independently promote learning, and are associated with neural signals separable from reward error signals.

DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.

Perception can occur in the absence of report. Here, the authors use intracranial recordings to show that sequential sampling of sensory evidence in the ventral visual cortex supports perception beyond report.

The morphogenetic events that occur during gastrulation involve dramatic cell- and tissue-level changes. Here they show that propagation of nematic order, leading to long-range spatial correlation, is universally conserved during metazoan embryogenesis.

There currently exists some debate as to exact mechanism of cation exchange in semiconductor nanocrystals, a crucial question regarding the fundamental materials chemistry of these systems. Here, the authors report a detailed investigation of the mechanism of cation exchange in nanocrystals, which unambiguously shows evidence of interstitial intermediates during the exchange process.