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Showing 1–50 of 53 results

Advanced filters: Author: Robert Hester Clear advanced filters

Interaction between high-velocity pulsar in CTB80 and an infrared emission shell

Robert A. Fesen
J. Michael Shull
Jon M. Saken
Research21 Jul 1988
Nature

Volume: 334, P: 229-231
Selective remodelling of the adipose niche in obesity and weight loss

An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problems caused by obesity.

Antonio M. A. Miranda
Liam McAllan
William R. Scott
ResearchOpen Access09 Jul 2025
Nature

Volume: 644, P: 769-779
Studying single living cells and chromosomes by confocal Raman microspectroscopy

G. J. Puppels
F. F. M. de Mul
T. M. Jovin
Research20 Sept 1990
Nature

Volume: 347, P: 301-303
A survey of human leukaemias for sequences of a human retrovirus

Flossie Wong-Staal
Beatrice Hahn
Robert C. Gallo
Research14 Apr 1983
Nature

Volume: 302, P: 626-628
Associations of autozygosity with a broad range of human phenotypes

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

David W Clark
Yukinori Okada
James F Wilson
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-17
Immune sera recognize on erythrocytes a Plasmodium falciparum antigen composed of repeated amino acid sequences

Ross L. Coppel
Alan F. Cowman
Graham V. Brown
Research30 Aug 1984
Nature

Volume: 310, P: 789-792
Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Using deep sequencing of human carotid plaque cells from male and female patients with carotid stenosis, Sukhavasi et al. identify sex-biased cell-type-specific gene-regulatory networks and different phenotypes in smooth muscle cells, including an osteogenic phenotype in females and a chondrocytic phenotype in males.

Katyayani Sukhavasi
Giuseppe Mocci
Johan L. M. Björkegren
ResearchOpen Access10 Apr 2025
Nature Cardiovascular Research

Volume: 4, P: 412-432
Impaired Error Awareness and Anterior Cingulate Cortex Hypoactivity in Chronic Cannabis Users

Robert Hester
Liam Nestor
Hugh Garavan
Research24 Jun 2009
Neuropsychopharmacology

Volume: 34, P: 2450-2458
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Doppler ultrasonography of the central retinal artery in patients with diabetes and vascular disease treated with topical timolol

Robert D Steigerwalt
Gianni Belcaro
Vicky Christopoulos
Research01 Jul 1995
Eye

Volume: 9, P: 495-501
Genetic studies of body mass index yield new insights for obesity biology

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

Adam E. Locke
Bratati Kahali
Elizabeth K. Speliotes
Research11 Feb 2015
Nature

Volume: 518, P: 197-206
Correction: Corrigendum: DNA sequence and analysis of human chromosome 18

Chad Nusbaum
Michael C. Zody
Eric S. Lander
Amendments and Corrections01 Dec 2005
Nature

Volume: 438, P: 696
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Multi-ancestry genome-wide association meta-analysis identifies new risk loci for CAC. Functional evidence implicates candidate causal genes as regulators of smooth muscle cell-mediated calcification.

Maryam Kavousi
Maxime M. Bos
Clint L. Miller
Research28 Sept 2023
Nature Genetics

Volume: 55, P: 1651-1664
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge

Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital pathology.

Wouter Bulten
Kimmo Kartasalo
Jeonghyuk Park
ResearchOpen Access13 Jan 2022
Nature Medicine

Volume: 28, P: 154-163
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

Anne E. Justice
Thomas W. Winkler
L Adrienne Cupples
ResearchOpen Access26 Apr 2017
Nature Communications

Volume: 8, P: 1-19
Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

Robert Hester
Cristina Simões-Franklin
Hugh Garavan
Research31 Jan 2007
Neuropsychopharmacology

Volume: 32, P: 1974-1984
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sample size together with genetic correlations between the phenotypes to identify, with high confidence, loci associated with each phenotype.

Aysu Okbay
Bart M L Baselmans
David Cesarini
Research18 Apr 2016
Nature Genetics

Volume: 48, P: 624-633
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 26-41
Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Mokry et al. performed bulk RNA sequencing of 654 advanced human carotid plaques from the Athero-Express biobank and 162 coronary samples, and they show that unsupervised clustering defines plaque types corresponding to different cell compositions and clinical presentations. Circulating biomarkers can be potentially used to mark the different transcriptomic-defined plaque phenotypes.

Michal Mokry
Arjan Boltjes
Gerard Pasterkamp
Research12 Dec 2022
Nature Cardiovascular Research

Volume: 1, P: 1140-1155
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

Helen McNeill and colleagues show that loss of Fat4, a homolog of the Drosophila planar cell polarity protein Fat, disrupts oriented cell division, leading to a failure of tubule elongation and cystic kidney disease in mice. The findings suggest that loss of planar cell polarity may underlie some forms of cystic kidney disease in humans.

Sakura Saburi
Ian Hester
Helen McNeill
Research06 Jul 2008
Nature Genetics

Volume: 40, P: 1010-1015
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

Leming Shi
Leming Shi
William Slikker Jr
Research08 Sept 2006
Nature Biotechnology

Volume: 24, P: 1151-1161
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new. Integration of gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.

Phuwanat Sakornsakolpat
Dmitry Prokopenko
Loems Zeigler-Heitbrock
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 494-505
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Aysu Okbay
Bart M L Baselmans
David Cesarini
Amendments and Corrections29 Nov 2016
Nature Genetics

Volume: 48, P: 1591
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Aysu Okbay
Bart M L Baselmans
David Cesarini
Amendments and Corrections27 Jul 2016
Nature Genetics

Volume: 48, P: 970
SARS-CoV-2 Spike S1-specific IgG kinetic profiles following mRNA or vector-based vaccination in the general Dutch population show distinct kinetics

Lotus L. van den Hoogen
Marije K. Verheul
Gerco den Hartog
ResearchOpen Access08 Apr 2022
Scientific Reports

Volume: 12, P: 1-6
Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation

Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as a key cargo in proliferating CD4+ T cells.

Dingxi Zhou
Mariana Borsa
Anna Katharina Simon
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Future global warming from atmospheric trace gases

Robert E. Dickinson
Ralph J. Cicerone
Reviews09 Jan 1986
Nature

Volume: 319, P: 109-115
TWINS DISCORDANT FOR INFECTION WITH HIV: A MULTI-DISCIPLINARY STUDY

Gary W Diamond
Robert W Marion
Herbert J Cohen
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 211
Serum metabolome associated with severity of acute traumatic brain injury

Traumatic brain injury is associated with changes to the metabolome. Here the authors show that acute traumatic brain injury has distinctive serum metabolic patterns which may suggest protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.

Ilias Thomas
Alex M. Dickens
Tommaso Zoerle
ResearchOpen Access10 May 2022
Nature Communications

Volume: 13, P: 1-15
Coastal pollution limits pelagic larval dispersal

Storm water runoff and wastewater effluent are discharged into oceans, but the full ecological effects of these discharges are unknown. Here, the authors examine the population structure of a marine organism, the bat star, and show that these discharges alter the genetic structure and larval dispersal of this species.

Jonathan B. Puritz
Robert J. Toonen
Research08 Mar 2011
Nature Communications

Volume: 2, P: 1-8
Immunization Practices Among Rural and Urban Clinicians 625

Lori Crane
Mark Deutchman
Stephen Berman
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 109
Studies of the Function and Structure of In Vitro Propagated Human Granulocytes

Robert W Frenck
Gerard J Ventura
E Stephen Buescher
Research01 Aug 1991
Pediatric Research

Volume: 30, P: 135-140
Brain Activation Associated with Attentional Bias in Smokers is Modulated by a Dopamine Antagonist

Maartje Luijten
Dick J Veltman
Ingmar H A Franken
Research01 Aug 2012
Neuropsychopharmacology

Volume: 37, P: 2772-2779
Ramularia leaf spot: PCR-based methods reveal widespread distribution of Ramulariopsis pseudoglycines and limited presence of R. gossypii in Brazil

Aline Suelen da Silva
Marcelo Henrique Lisboa Rennó
Danilo Batista Pinho
ResearchOpen Access17 Jun 2023
Scientific Reports

Volume: 13, P: 1-13
Africans and Europeans differ in their facial perception of dominance and sex-typicality: a multidimensional Bayesian approach

Vojtěch Fiala
Petr Tureček
Karel Kleisner
ResearchOpen Access26 Apr 2022
Scientific Reports

Volume: 12, P: 1-15
DNA sequence and analysis of human chromosome 18

Chad Nusbaum
Michael C. Zody
Eric S. Lander
Research22 Sept 2005
Nature

Volume: 437, P: 551-555
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1191-1192
Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group

Sally Grace
Maria Gloria Rossetti
Valentina Lorenzetti
ResearchOpen Access04 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-15
Accelerated increase in plant species richness on mountain summits is linked to warming

Analysis of changes in plant species richness on mountain summits over the past 145 years suggests that increased climatic warming has led to an acceleration in species richness increase.

Manuel J. Steinbauer
John-Arvid Grytnes
Sonja Wipf
Research04 Apr 2018
Nature

Volume: 556, P: 231-234
The need for bottom-up assessments of climate risks and adaptation in climate-sensitive regions

Top-down studies of climate change use climate projections and modelled impacts, whereas bottom-up assessments focus on the recent past and present vulnerability. This Perspective argues that these approaches must be integrated to address the needs of immediate adaptation decisions.

Declan Conway
Robert J. Nicholls
Philippus Wester
Reviews17 Jun 2019
Nature Climate Change

Volume: 9, P: 503-511
Evidence that the Acute Behavioral and Electrophysiological Effects of Bupropion (Wellbutrin®) Are Mediated by a Noradrenergic Mechanism

Barrett R. Cooper
Ching M. Wang
Robert M. Ferris
Research01 Oct 1994
Neuropsychopharmacology

Volume: 11, P: 133-141
Immunomodulatory Components Present in IMREG-1, an Experimental Immunosupportive Biologic

Sudhir K. Sinha
Robert C. Sizemore
A. Arthur Gottlieb
Research01 Jul 1988
Bio/Technology

Volume: 6, P: 810-815
TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury

Shubhayu Bhattacharyay
Florian D. van Leeuwen
Tommaso Zoerle
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-18
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles

Using flow cytometry and transcriptomic analyses, the authors characterize the functional diversity of B cell subsets in the lungs of patients with tuberculosis.

Robert Krause
Paul Ogongo
Al Leslie
ResearchOpen Access16 May 2024
Communications Biology

Volume: 7, P: 1-15
Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group

Maria Gloria Rossetti
Scott Mackey
Valentina Lorenzetti
ResearchOpen Access06 May 2021
Translational Psychiatry

Volume: 11, P: 1-11
Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists

Wouter Bulten
Maschenka Balkenhol
Geert Litjens
ResearchOpen Access05 Aug 2020
Modern Pathology

Volume: 34, P: 660-671
Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load

Simone Haeberlein
Séverine Chevalley-Maurel
Blandine Franke-Fayard
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-19

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