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Showing 1–2 of 2 results
Advanced filters: Author: Roberto Bellelli Clear advanced filters

  • The ectoenzyme CD73 is often elevated in tumour environments and targeting this protein is a tumour therapeutic target. Here the authors characterise a therapeutic anti-CD73 antibody cocktail which is more effective than either antibody alone and suggest a molecular mechanism of how this antibody cocktail functions.

    • Jin-Gen Xu
    • Shi Chen
    • Li Wan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Covalent DNA–protein crosslinks (DPCs) are induced by various compounds, which include widely used anticancer drugs, and are highly cytotoxic. Recent studies have revealed the mechanisms and the regulation of DPC repair pathways and suggest that components of these pathways can serve as targets for anticancer therapies.

    • Julian Stingele
    • Roberto Bellelli
    • Simon J. Boulton
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 563-573