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Showing 1–5 of 5 results
Advanced filters: Author: Robyn Domsic Clear advanced filters

  • Systemic sclerosis is associated with a high level of patient mortality. A promising prognostic model that could enable more effective management and improve survival was recently validated; however, the results demonstrate that choosing the best cohorts for development and validation of predictors of mortality is essential.

    • Robyn T. Domsic
    • Thomas A. Medsger Jr
    News & Views
    Nature Reviews Rheumatology
    Volume: 7, P: 628-630

  • Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.

    • Tracy Tabib
    • Mengqi Huang
    • Robert Lafyatis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The updated 2023 EULAR recommendations for treatment of systemic sclerosis bring notable changes to recommendations for skin, peripheral vascular disease, interstitial lung disease and pulmonary arterial hypertension therapies, based on newer evidence. These updates provide the first glimmer of personalized patient management.

    • Robyn T. Domsic
    News & Views
    Nature Reviews Rheumatology
    Volume: 21, P: 133-134

  • The diagnosis, treatment and management of systemic sclerosis (SSc) remains challenging, owing to the complexity of this disease. In this Perspective, an international group of experts discuss the future of SSc research and how the advent of innovative technologies will advance research into and understanding of SSc.

    • David J. Abraham
    • Carol M. Black
    • Thomas Krieg
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 174-187