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Showing 1–6 of 6 results
Advanced filters: Author: Rod Chalk Clear advanced filters

  • The Main protease of SARS-CoV-2 is key for viral replication, but its maturation process is still not completely understood. Here, the authors not only reveal unique details from the first step of maturation, but also demonstrate how different classes of inhibitor can block this step.

    • Gabriela Dias Noske
    • Yun Song
    • Andre Schutzer Godoy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Pascoa et al. reveal structures of the human ceramide synthase 6 and elucidate the enzyme’s mechanism. Furthermore, the work uncovers the basis of inhibition by the mycotoxin fumonisin B1.

    • Tomas C. Pascoa
    • Ashley C. W. Pike
    • David B. Sauer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 431-440

  • Reliable intracellular delivery of antibodies is one of the grand challenges in biomedical research, with the potential to address unmet clinical needs or to enable basic research. Now, it has been shown that tricyclic peptide complexes can transport functional antibodies into the cytoplasm and nucleus of cells to specifically target intracellular proteins.

    • Ole Tietz
    • Fernando Cortezon-Tamarit
    • Katherine A. Vallis
    Research
    Nature Chemistry
    Volume: 14, P: 284-293

  • The human enzyme MTHFR links the folate and methionine cycles, which are essential for the biosynthesis of nucleotides and proteins. Here, the authors present the crystal structure and biochemical analysis of human MTHFR, providing molecular insights into its function and regulation in higher eukaryotes.

    • D. Sean Froese
    • Jolanta Kopec
    • Wyatt W. Yue
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Mapping multiple glycan species to the same peptide and location from shared retention time of glycopeptides with MS and HPLC, Chalk, Greenland et al. construct a detailed mass-retention time database for Spike protein glycopeptides. This allows any mass LC-MS laboratory to reliably identify and quantify Spike protein glycopeptides from a single overnight elastase protein digest in less than 90 minutes.

    • Rod Chalk
    • William E. P. Greenland
    • Nicola A. Burgess-Brown
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-8

  • The cryo-EM structure of human polycystin-2 (PC2) in a closed conformation reveals a domain located above the pore filter, forming an upper vestibule and making contacts with the pore and voltage-sensor-like domains.

    • Mariana Grieben
    • Ashley C W Pike
    • Elisabeth P Carpenter
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 114-122