Excessive exposure to visible light damages the vertebrate retina. New work demonstrates that two different pathways, a bright-light pathway and a low-light dependent pathway, mediate light-induced retinal death. Although both pathways are initiated by excessive activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is AP-1-dependent and only the low-light pathway is dependent on phototransduction.
- Samuel G. Jacobson
- Roderick R. McInnes