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Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that viral genetic factors contribute substantially to the HIV-1 reservoir size.

Chenjie Wan
Nadine Bachmann
Sabine Yerly
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Phylogenetics and molecular evolution to understand and curb the HIV pandemic

In this Review, Günthard, Kusejko and Kouyos examine how advances in phylogenetics and molecular epidemiology have deepened our understanding of the HIV pandemic, including tracing its zoonotic origins, monitoring transmission dynamics and prevention efforts, and understanding pathogenesis.

Huldrych F. Günthard
Katharina Kusejko
Roger D. Kouyos
Reviews30 Jun 2025
Nature Reviews Microbiology

P: 1-17
Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

Similarity of antibody responses in HIV-1 transmission pairs reveals a significant impact of the virus genome on imprinting antibody responses.

Roger D. Kouyos
Peter Rusert
Sabine Yerly
Research10 Sept 2018
Nature

Volume: 561, P: 406-410
Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Here, Bachmann et al. provide data on long-term dynamics of the HIV-1 reservoir in 1,057 individuals on suppressive antiretroviral therapy and show that in 26.6% of individuals the reservoir increases. Viral blips and low-level viremia are significantly associated with a slower reservoir decay.

Nadine Bachmann
Chantal von Siebenthal
Sabine Yerly
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-11
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

How the immune responses induced by SARS-CoV-2 and human coronavirus (hCoV) crosstalk is still unclear. Here the authors profile the humoral responses of prepandemic and SARS-CoV-2-infected donors to find that higher hCoV antibody titers are associated with SARS-CoV-2 negativity, and with reduced hospitalization in SARS-CoV-2 positive patients.

Irene A. Abela
Chloé Pasin
Alexandra Trkola
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis

Individuals seeking post-exposure prophylaxis (PEP) for HIV may represent an important risk group for future HIV infection. Here the authors find HIV infections at long-term follow-up in 22 of 348 men who have sex with men, and 0 of 623 other PEP seekers.

Frédérique Hovaguimian
Huldrych F. Günthard
S. Yerly
ResearchOpen Access22 Feb 2021
Nature Communications

Volume: 12, P: 1-8
Determinants of HIV-1 broadly neutralizing antibody induction

Broadly neutralizing antibodies (bnAbs) develop in a minority of HIV-infected individuals. Analyzing data from more than 4,000 infected individuals, Alexandra Trkola and colleagues identify viral, host and disease factors associated with the development of bNAbs that may inform future vaccine design.

Peter Rusert
Roger D Kouyos
Rainer Weber
Research26 Sept 2016
Nature Medicine

Volume: 22, P: 1260-1267
Parallel dynamics in the yield of universal SARS-CoV-2 admission screening and population incidence

Peter W. Schreiber
Thomas Scheier
Walter Zingg
ResearchOpen Access05 May 2023
Scientific Reports

Volume: 13, P: 1-7
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.

Nikolas Friedrich
Emanuel Stiegeler
Alexandra Trkola
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland

Mohaned Shilaih
Alex Marzel
Reiner Weber
ResearchOpen Access14 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
A Direct Comparison of Two Densely Sampled HIV Epidemics: The UK and Switzerland

Manon L. Ragonnet-Cronin
Mohaned Shilaih
Andrew J. Leigh Brown
ResearchOpen Access19 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
Author Correction: Efficient microbial colony growth dynamics quantification with ColTapp, an automated image analysis application

Julian Bär
Mathilde Boumasmoud
Clément Vulin
Amendments and CorrectionsOpen Access09 Mar 2021
Scientific Reports

Volume: 11, P: 1
Assessing immunogenicity barriers of the HIV-1 envelope trimer

Liridona Maliqi
Nikolas Friedrich
Alexandra Trkola
ResearchOpen Access30 Sept 2023
npj Vaccines

Volume: 8, P: 1-14
Efficient microbial colony growth dynamics quantification with ColTapp, an automated image analysis application

Julian Bär
Mathilde Boumasmoud
Clément Vulin
ResearchOpen Access30 Sept 2020
Scientific Reports

Volume: 10, P: 1-15
Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector

Yik Lim Kok
Stefan Schmutz
Karin J. Metzner
ResearchOpen Access05 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4⁺ T cells

Yik Lim Kok
Valentina Vongrad
Karin J. Metzner
ResearchOpen Access12 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
The influence of human genetic variation on Epstein–Barr virus sequence diversity

Sina Rüeger
Christian Hammer
Sabine Yerly
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-12
Author Correction: The influence of human genetic variation on Epstein–Barr virus sequence diversity

Sina Rüeger
Christian Hammer
Sabine Yerly
Amendments and CorrectionsOpen Access20 Apr 2021
Scientific Reports

Volume: 11, P: 1

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