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Correction: Corrigendum: The receptor NLRP3 is a transcriptional regulator of T_H2 differentiation

Mélanie Bruchard
Cédric Rebé
François Ghiringhelli
Amendments and Corrections01 Dec 2015
Nature Immunology

Volume: 16, P: 1292
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

In a large multicentric study of patients with advanced NSCLC undergoing anti-PD-1 therapy, the relative abundance of intestinal Akkermansia spp. was shown to associate with changes in the gut microbiome ecosystem and clinical outcomes.

Lisa Derosa
Bertrand Routy
Benjamin Besse
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 315-324
First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial

Treatment with anti-PDL1 and anti-CTLA4 in combination with mFOLFOX6 chemotherapy for patients with treatment-naive microsatellite stable metastatic colorectal cancer is safe, shows encouraging progression-free survival and induces a tumor-specific immune response.

Marion Thibaudin
Jean-David Fumet
François Ghiringhelli
ResearchOpen Access10 Aug 2023
Nature Medicine

Volume: 29, P: 2087-2098
PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma

Resistance to anti-EGFR therapy is a clinical issue for patients with advanced head and neck cancers. Here, the authors show that therapy-resistant cancer cells enhance fatty acid metabolism, which can be therapeutically targeted by inhibiting peroxisome proliferator-activated receptor alpha (PPARα).

Valentin Van den bossche
Julie Vignau
Cyril Corbet
ResearchOpen Access01 Feb 2025
Nature Communications

Volume: 16, P: 1-21
The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers

The oral antibiotic adsorbent DAV132 can reduce fecal concentrations of antibiotics while preserving their pharmacokinetic properties. Here, in a randomized trial in healthy volunteers treated with antibiotics, the authors show that DAV132 does not affect plasma concentrations of the antibiotics but preserves microbiome diversity and composition, with implications for cancer immunotherapy.

Meriem Messaoudene
Stéphanie Ferreira
Bertrand Routy
ResearchOpen Access15 Sept 2024
Nature Communications

Volume: 15, P: 1-19
The intrinsic expression of NLRP3 in Th17 cells promotes their protumor activity and conversion into Tregs

Théo Accogli
Christophe Hibos
Frédérique Vegran
ResearchOpen Access07 Apr 2025
Cellular & Molecular Immunology

Volume: 22, P: 541-556
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses

The function of type 3 innate lymphoid cells (ILC3s) in cancer is still poorly understood. Bruchard et al. demonstrate that ILC3s are critical for the recruitment of T cells to the tumor microenvironment and thereby play important roles in antitumor responses.

Mélanie Bruchard
Mannon Geindreau
François Ghiringhelli
Research31 Jan 2022
Nature Immunology

Volume: 23, P: 262-274
Transcriptome-wide identification of transient RNA G-quadruplexes in human cells

In vivo existence of guanine-rich four-stranded RNA structures (G4-RNAs) has been a matter of debate. Here the authors developed a protocol, G4RP-seq, to capture and identify transcriptome-wide G4-RNA, providing insights into the formation of transient G4-RNA in live human cells.

Sunny Y. Yang
Pauline Lejault
David Monchaud
ResearchOpen Access09 Nov 2018
Nature Communications

Volume: 9, P: 1-11
IRF8-dependent molecular complexes control the Th9 transcriptional program

Interferon regulatory factors IRF regulate lymphoid development, but the specific function of IRF8 in helper T-cell polarization is unclear. Here the authors show that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription program and expression of IL-4 and IL-9.

Etienne Humblin
Marion Thibaudin
François Ghiringhelli
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-13
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of T_H9 cells

T_H9 cells are associated with autoinflammatory diseases. Apetoh and colleagues demonstrate a molecular pathway which converts T_H9 cells into potent anticancer cells.

Frédérique Végran
Hélène Berger
Lionel Apetoh
Research29 Jun 2014
Nature Immunology

Volume: 15, P: 758-766
The receptor NLRP3 is a transcriptional regulator of T_H2 differentiation

The receptor NLRP3 is central to the formation of inflammasomes in myeloid cells. Ghiringhelli and colleagues demonstrate that NLRP3 also serves an important inflammasome-independent role in CD4⁺ T cells, in which it helps coordinate T_H2 differentiation.

Mélanie Bruchard
Cédric Rebé
François Ghiringhelli
Research22 Jun 2015
Nature Immunology

Volume: 16, P: 859-870
PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy

Zoé Tharin
Corentin Richard
Sylvain Ladoire
ResearchOpen Access18 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Correction: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues

Valérie Glorian
Jennifer Allègre
Laurence Dubrez
Amendments and CorrectionsOpen Access16 Jul 2018
Cell Death & Disease

Volume: 9, P: 1
Efficacy of platinum-based chemotherapy in metastatic breast cancer and HRD biomarkers: utility of exome sequencing

Loïck Galland
Elise Ballot
Sylvain Ladoire
ResearchOpen Access04 Mar 2022
npj Breast Cancer

Volume: 8, P: 1-12
Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations

Anthony Bergeron
Gaëtan MacGrogan
Laurent Arnould
Research22 Mar 2021
Modern Pathology

Volume: 34, P: 1282-1296
Impact of proton therapy on antitumor immune response

Céline Mirjolet
Anaïs Nicol
Hélène Burckel
ResearchOpen Access29 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract

Virginie Aires
Jérôme Labbé
Laurent Lagrost
ResearchOpen Access24 Jun 2019
Scientific Reports

Volume: 9, P: 1-16
Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations

Julie Massé
Caroline Truntzer
Gaëtan MacGrogan
Research19 Dec 2019
Modern Pathology

Volume: 33, P: 1041-1055
Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases

Nadjla Alsadoun
Gaëtan MacGrogan
Laurent Arnould
Research21 May 2018
Modern Pathology

Volume: 31, P: 1367-1380
Somatic substitution signature as an innovative tool in lung cancer diagnosis

Stéphane Busca
Julia Salleron
Alexandre Harlé
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Jean-David Fumet
Corentin Richard
François Ghiringhelli
ResearchOpen Access15 Oct 2018
British Journal of Cancer

Volume: 119, P: 950-960
Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Jean-David Fumet
Corentin Richard
François Ghiringhelli
Amendments and CorrectionsOpen Access24 Jun 2019
British Journal of Cancer

Volume: 121, P: 283
DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues

Valérie Glorian
Jennifer Allègre
Laurence Dubrez
ResearchOpen Access25 May 2017
Cell Death & Disease

Volume: 8, P: e2816

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Correction: Corrigendum: The receptor NLRP3 is a transcriptional regulator of T_H2 differentiation

Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial

PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma

The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers

The intrinsic expression of NLRP3 in Th17 cells promotes their protumor activity and conversion into Tregs

Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses

Transcriptome-wide identification of transient RNA G-quadruplexes in human cells

IRF8-dependent molecular complexes control the Th9 transcriptional program

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of T_H9 cells

The receptor NLRP3 is a transcriptional regulator of T_H2 differentiation

PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy

Correction: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues

Efficacy of platinum-based chemotherapy in metastatic breast cancer and HRD biomarkers: utility of exome sequencing

Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations

Impact of proton therapy on antitumor immune response

Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract

Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations

Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases

Somatic substitution signature as an innovative tool in lung cancer diagnosis

Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues

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