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Showing 151–200 of 205 results

Advanced filters: Author: Ronald C Petersen Clear advanced filters

Are plasma markers for Alzheimer’s disease ready for clinical use?

Plasma biomarkers pertaining to the underlying pathophysiology of Alzheimer’s disease have recently become available (for example, amyloid beta and phosphorylated tau). The utility of these markers poses a question for clinicians (now and in the future): are plasma biomarkers for Alzheimer’s disease are ready for clinical use at this time?

Ronald C. Petersen
Comments & Opinion17 Feb 2022
Nature Aging

Volume: 2, P: 94-96
A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

Peng Liu
Benjamin R. Smith
Karen H. Ashe
ResearchOpen Access02 Mar 2020
Scientific Reports

Volume: 10, P: 1-18
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan
Jingjing Liang
Xinglong Wang
Amendments and CorrectionsOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-2
Understanding metric-related pitfalls in image analysis validation

This Perspective presents a reliable and comprehensive source of information on pitfalls related to validation metrics in image analysis, with an emphasis on biomedical imaging.

Annika Reinke
Minu D. Tizabi
Lena Maier-Hein
Reviews12 Feb 2024
Nature Methods

Volume: 21, P: 182-194
Bax cleavage is mediated by calpain during drug-induced apoptosis

David E Wood
Anju Thomas
Elizabeth W Newcomb
Research04 Sept 1998
Oncogene

Volume: 17, P: 1069-1078
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells

Hsin-Ling Hsu
Bo Shi
Ronald B Gartenhaus
Research25 Apr 2005
Oncogene

Volume: 24, P: 4956-4964
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117
Expression and stabilization of the MCT-1 protein by DNA damaging agents

Gregory B Herbert
Bo Shi
Ronald B Gartenhaus
Research19 Oct 2001
Oncogene

Volume: 20, P: 6777-6783
X‐chromosome-wide association study for Alzheimer’s disease

Julie Le Borgne
Lissette Gomez
Céline Bellenguez
ResearchOpen Access04 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2335-2346
A validation study demonstrating portable motion capture cameras accurately characterize gait metrics when compared to a pressure-sensitive walkway

Kevin A. Mazurek
Leland Barnard
Farwa Ali
ResearchOpen Access29 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Vivianna Van Deerlin and colleagues report that common variants at 7p21 are associated with a subtype of frontotemporal lobar degeneration marked by TDP-43 inclusions. They further show that the risk alleles are associated with elevated brain expression of TMEM106B, which resides at the peak of association on 7p21.

Vivianna M Van Deerlin
Patrick M A Sleiman
Virginia M-Y Lee
Research14 Feb 2010
Nature Genetics

Volume: 42, P: 234-239
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath
John C. Earls
Yi Zhao
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
Alzheimer disease

Alzheimer disease is a neurodegenerative disorder that causes cognitive impairment. This Primer by Knopman et al. reviews the epidemiology of cognitive manifestations and risk factors, summarizes the pathophysiology from a synaptic disorder perspective, and reviews advances in the diagnosis, management and quality of life of persons living with Alzheimer disease.

David S. Knopman
Helene Amieva
David T. Jones
Reviews13 May 2021
Nature Reviews Disease Primers

Volume: 7, P: 1-21
Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

Peng Liu
Benjamin R. Smith
Karen H. Ashe
Amendments and CorrectionsOpen Access12 May 2020
Scientific Reports

Volume: 10, P: 1
International network of cancer genome projects

Thomas J. Hudson (Chairperson)
Warwick Anderson
Huanming Yang
Reviews15 Apr 2010
Nature

Volume: 464, P: 993-998
The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian
Yousef Jamali
Ansgar J. Furst
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-17
A genome-wide linkage and association scan reveals novel loci for autism

Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

Lauren A. Weiss
Dan E. Arking
Leena Peltonen
Research08 Oct 2009
Nature

Volume: 461, P: 802-808
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Yeonwoo Chung
Hyunju Lee
Kristin Fargher
ResearchOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns

Jong-Yun Park
Han Kyu Na
Balebail Ashok Raj
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Sheng-Yao Huang
Jung-Lung Hsu
Balebail Ashok Raj
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
The role of NFκB in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine

Sascha Kopp
Jayashree Sahana
Daniela Grimm
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Asha Singanamalli
Haibo Wang
Kristin Fargher
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience

Clare Bryce
Zachary Grimes
Mary E. Fowkes
Research01 Apr 2021
Modern Pathology

Volume: 34, P: 1456-1467
Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Xinpeng Shen
Sisi Ma
Kristin Fargher
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Janina Krell-Roesch
Maria Vassilaki
Yonas E. Geda
ResearchOpen Access28 Mar 2019
Translational Psychiatry

Volume: 9, P: 1-8
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du
Kefei Liu
Kristin Fargher
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease

Haochen Liu
Xiaoting Zhou
Kristin Fargher
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

Yogatheesan Varatharajah
Vijay K. Ramanan
Kristin Fargher
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
ResearchOpen Access25 Sept 2019
Scientific Reports

Volume: 9, P: 1-16
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Margherita Squillario
Giulia Abate
Kristin Fargher
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Author Correction: Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies

Elijah Mak
Robert I. Reid
Kejal Kantarci
Amendments and CorrectionsOpen Access12 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Joana Carlevaro-Fita, Andrés Lanzós et al. present the Cancer LncRNA Census (CLC), a manually curated dataset of 122 long noncoding RNAs (lncRNAs) with experimentally-validated functions in cancer based on data from the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. CLC lncRNAs have unique gene features, and a number display evidence for cancer-driving functions that are conserved from humans to mice.

Joana Carlevaro-Fita
Andrés Lanzós
Christian von Mering
ResearchOpen Access05 Feb 2020
Communications Biology

Volume: 3, P: 1-16
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Suprateek Kundu
Joshua Lukemire
Ansgar J. Furst
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-18
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Wei Xu
Hui-Fu Wang
Kristin Fargher
ResearchOpen Access27 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity

Jung-Min Pyun
Young Ho Park
Zaven Khachaturian
ResearchOpen Access10 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-9
A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Benjamin Goudey
Bowen J. Fung
Brenda Plassman
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

Lin Tan
Hui-Fu Wang
Kristin Fargher
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-12
Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Ines Mahjoub
Mohamed Ali Mahjoub
Kristin Fargher
ResearchOpen Access07 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Emrin Horgusluoglu-Moloch
Shannon L. Risacher
Kristin Fargher
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease

Xiaoke Hao
Chanxiu Li
Kristin Fargher
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

Meiyan Huang
Wei Yang
Kristin Fargher
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Yixin Gao
Ting Wang
Ping Zeng
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Donghuan Lu
Karteek Popuri
Kristin Fargher
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-13

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