Nature Search

Contaminated aquifers are a forgotten component of the global N₂O budget

Daniel Ronen
Mordeckai Magaritz
Ehud Almon
Research01 Sept 1988
Nature

Volume: 335, P: 57-59
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

Nanda A. Singh
Carole Charlier
Mark Leppert
Research01 Jan 1998
Nature Genetics

Volume: 18, P: 25-29
Crystal structure of a PUT3–DNA complex reveals a novel mechanism for DMA recognition by a protein containing a Zn₂Cys₆ binuclear cluster

Kunchithapadam Swaminathan
Paul Flynn
Ronen Marmorstein
Research01 Sept 1997
Nature Structural Biology

Volume: 4, P: 751-759
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

Antibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct interaction modes in crystal structure, and mediate protection in vitro.

Avia Watson
Hao Li
Natalia T. Freund
ResearchOpen Access27 Jan 2021
Nature Communications

Volume: 12, P: 1-11
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.

Yfat Yahalom-Ronen
Hadas Tamir
Tomer Israely
ResearchOpen Access16 Dec 2020
Nature Communications

Volume: 11, P: 1-13
Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

In this study, the authors show that a single dose of a combination of two human-like monoclonal antibodies protect mice in therapeutic treatment against challenges with ectromelia virus and monkeypox virus. Combination treatment provided more effective viral clearance than single antibody treatment.

Hadas Tamir
Tal Noy-Porat
Tomer Israely
ResearchOpen Access16 Apr 2024
Nature Communications

Volume: 15, P: 1-10
The coding capacity of SARS-CoV-2

A high-resolution map of coding regions in the SARS-CoV-2 genome enables the identification of 23 unannotated open reading frames and quantification of the expression of canonical viral open reading frames.

Yaara Finkel
Orel Mizrahi
Noam Stern-Ginossar
Research09 Sept 2020
Nature

Volume: 589, P: 125-130
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity

Influenza A virus (IAV) and SARS-CoV-2 coinfection is a possible scenario during influenza season. Here, the authors show in a mouse model that IAV infection increases the risk of severe disease upon SARS-CoV-2 infection two days later. IAV vaccination, especially antibody-dependent, protects from severe disease during coinfection.

Hagit Achdout
Einat. B. Vitner
Tomer Israely
ResearchOpen Access05 Oct 2021
Nature Communications

Volume: 12, P: 1-10
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities against authentic virus in vitro.

Tal Noy-Porat
Efi Makdasi
Ronit Rosenfeld
ResearchOpen Access27 Aug 2020
Nature Communications

Volume: 11, P: 1-7
Choline metabolism in malignant transformation

Choline metabolism is commonly deregulated in cancer, leading to increased levels of choline metabolites. This Review discusses the deregulation of choline metabolism in cancer, its reciprocal interaction with oncogenic signalling and the possible clinical applications in diagnostics and therapy.

Kristine Glunde
Zaver M. Bhujwalla
Sabrina M. Ronen
Reviews17 Nov 2011
Nature Reviews Cancer

Volume: 11, P: 835-848
Food-seeking behavior is triggered by skin ultraviolet exposure in males

Ultraviolet exposure on the skin promotes food intake and body weight gain in males, but not females, by increasing ghrelin expression in skin adipocytes.

Shivang Parikh
Roma Parikh
Carmit Levy
ResearchOpen Access11 Jul 2022
Nature Metabolism

Volume: 4, P: 883-900
SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

RNA sequencing, ribosome profiling and metabolic labelling of newly synthesized RNA reveal the strategy used by SARS-CoV-2 to shut off cellular protein synthesis in the host and allow the translation of viral transcripts.

Yaara Finkel
Avi Gluck
Noam Stern-Ginossar
Research12 May 2021
Nature

Volume: 594, P: 240-245
Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

Here, Israeli and Finkel et al. perform genome-wide CRISPR knockout screens to identify host factors required for the infection with SARS-CoV-2 and two additionally variants of concern, Alpha and Beta, unveiling shared and differential host pathways required by the variants, and demonstrate GATA6 is critical for SARS-CoV-2 viral entry through modulation of ACE2 expression.

Ma’ayan Israeli
Yaara Finkel
Adi Bercovich-Kinori
ResearchOpen Access25 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome

Gholson J. Lyon
Marall Vedaie
Ellen Herr-Israel
ResearchOpen Access02 May 2023
European Journal of Human Genetics

Volume: 31, P: 824-833
Myxoinflammatory fibroblastic sarcoma: an immunohistochemical and molecular genetic study of 73 cases

David Suster
Michael Michal
A. Craig Mackinnon
Research08 Jun 2020
Modern Pathology

Volume: 33, P: 2520-2533
Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans

Apoptotic cell corpses are engulfed and removed through an evolutionarily conserved pathway. In Caenorhabditis elegans, inhibition of the Rac GAP SRGP-1 permits sick or dying cells to escape clearance by this pathway.

Lukas J. Neukomm
Andreas P. Frei
Michael O. Hengartner
Research19 Dec 2010
Nature Cell Biology

Volume: 13, P: 79-86

Search

Contaminated aquifers are a forgotten component of the global N₂O budget

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

Crystal structure of a PUT3–DNA complex reveals a novel mechanism for DMA recognition by a protein containing a Zn₂Cys₆ binuclear cluster

Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

The coding capacity of SARS-CoV-2

Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity

A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

Choline metabolism in malignant transformation

Food-seeking behavior is triggered by skin ultraviolet exposure in males

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome

Myxoinflammatory fibroblastic sarcoma: an immunohistochemical and molecular genetic study of 73 cases

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans

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