Ye et al. mimic a natural pathway for IgG transfer to deliver a vaccine across mucosal barriers. Intranasal immunization of mice with a fusion of a herpes simplex virus type-2 (HSV-2) antigen to an Fc fragment induces long-lasting protection after intravaginal challenge with HSV-2.
- Lilin Ye
- Rongyu Zeng
- Xiaoping Zhu