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Showing 1–3 of 3 results
Advanced filters: Author: Rosslyn Grosely Clear advanced filters

  • Using single-molecule analysis, the authors establish that direct competition between eIF1 and eIF5 governs accurate yet flexible translation initiation in humans, providing a biophysical framework with broad relevance to health and disease.

    • Rosslyn Grosely
    • Carlos Alvarado
    • Christopher P. Lapointe
    Research
    Nature Structural & Molecular Biology
    P: 1-11

  • Single-molecule spectroscopy and structural studies were used to examine the dynamics of association of eIF1A and eIF5B with the human translation initiation complex and their role in presenting tRNA to the complex to initiate translation.

    • Christopher P. Lapointe
    • Rosslyn Grosely
    • Joseph D. Puglisi
    Research
    Nature
    Volume: 607, P: 185-190

  • A nucleotide repeat expansion in the C9orf72 gene is the most common cause of amyotrophic lateral sclerosis. The mutation causes production of aberrant proteins by an enigmatic form of translation. Yamada et al. identify that RPS25 is required for this form of translation.

    • Shizuka B. Yamada
    • Tania F. Gendron
    • Aaron D. Gitler
    Research
    Nature Neuroscience
    Volume: 22, P: 1383-1388