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Showing 1–4 of 4 results
Advanced filters: Author: Roxanne Oshidari Clear advanced filters

  • Genome dynamics allow cells to repair DNA double-strand breaks (DSBs), which are highly toxic DNA lesions. Here the authors reveal that in S. cerevisiae, Rad52 DNA repair proteins assemble in liquid droplets that work with dynamic nuclear microtubules to relocalize lesions to the nuclear periphery for repair.

    • Roxanne Oshidari
    • Richard Huang
    • Karim Mekhail
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • RNA polymerase II has an unexpected function in the nucleolus, helping to drive the expression of ribosomal RNA and to protect nucleolar structure through a mechanism involving triplex R-loop structures.

    • Karan J. Abraham
    • Negin Khosraviani
    • Karim Mekhail
    Research
    Nature
    Volume: 585, P: 298-302

  • Lauren Ostrowski, Amanda Hall et al. report a molecular characterization of Pbp1, the yeast ortholog of the neurodegenerative disease-associated human ATXN2. They find that Pbp1 knockout or polyQ expansion compromises rDNA repeat stability via a mechanism linking neurodegenerative protein aggregation and aging.

    • Lauren A. Ostrowski
    • Amanda C. Hall
    • Karim Mekhail
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-17