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Showing 1–8 of 8 results
Advanced filters: Author: Roy Zent Clear advanced filters
  • Polycystic kidney disease (PKD) is characterized by the formation of large fluid-filled cysts. Here Flowers and colleagues show that loss of Lkb1, downregulated in PKD, renders kidney cells dependent on glutamine for growth, and suggest that inhibition of glutamine metabolism may prevent cyst development in PKD.

    • Ebony M. Flowers
    • Jessica Sudderth
    • Thomas J. Carroll
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11
  • The mechanosensitive proteins talin and vinculin mediate the linkage between integrin-bound extracellular matrix and the actin cytoskeleton. Here the authors dissect distinct roles for two actin-binding sites within talin on adhesion complex assembly and maturation, which are regulated by vinculin binding to talin.

    • Paul Atherton
    • Ben Stutchbury
    • Christoph Ballestrem
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12
  • Integrins are heterodimeric transmembrane receptors that mediate crucial interactions between cells and extracellular matrix to regulate cellular functions such as intracellular signalling and organization of the actin cytoskeleton. This Review highlights the roles of integrins and integrin-binding proteins in the control of kidney-cell morphology and functions as well as their role in kidney diseases

    • Fabian Bock
    • Shensen Li
    • Roy Zent
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 157-174
  • Integrin-linked kinase (Ilk) is a multifunctional protein that binds β-integrin cytoplasmic domains and regulates actin dynamics through the recruitment of actin binding regulatory proteins such as α- and β-parvin. In mice, genetic evidence is now provided that the kinase activity of Ilk is not essential for mammalian development but that an interaction between Ilk and α-parvin is critical for kidney development.

    • Anika Lange
    • Sara A. Wickström
    • Reinhard Fässler
    Research
    Nature
    Volume: 461, P: 1002-1006
  • Austen et al. generated talin biosensors to study integrin-based force transduction. They report that extracellular rigidity sensing requires talin’s mechanical engagement and find talin isoform-dependent effects in integrin-mediated mechanosensing.

    • Katharina Austen
    • Pia Ringer
    • Carsten Grashoff
    Research
    Nature Cell Biology
    Volume: 17, P: 1597-1606