Nature Search

Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.

Yun-Nian Yin
Rui-Qi Ding
Rong Zhu
ResearchOpen Access05 May 2021
Nature Communications

Volume: 12, P: 1-10
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control

The gut-microbiota-derived aromatic amino acid metabolite 4-hydroxyphenylacetic acid (4HPAA) and its analogues have been shown to protect against obesity. In mice, 4HPAA exerts anti-obesogenic effects by modulating mucosal immunity and lipid uptake in the intestine.

Zengliang Jiang
Liuqing He
Liang Tao
ResearchOpen Access14 Mar 2025
Nature Metabolism

Volume: 7, P: 808-822
The hornwort genome and early land plant evolution

A draft genome sequence of the hornwort Anthoceros augustus confirms the phylogenetic relationships among the three clades of bryophytes and provides insight into the unique characteristics of hornworts and their adaptations to live on land.

Jian Zhang
Xin-Xing Fu
Zhi-Duan Chen
ResearchOpen Access10 Feb 2020
Nature Plants

Volume: 6, P: 107-118
Personality traits and brain health: a large prospective cohort study

Using a large dataset of approximately 300,000 individuals from the UK Biobank, Zhang, Deng, Li et al. investigated the relationships between personality traits, brain health, inflammation and metabolites.

Ya-Ru Zhang
Yue-Ting Deng
Jin-Tai Yu
Research04 Sept 2023
Nature Mental Health

Volume: 1, P: 722-735
TGF-β1 Upregulates the Expression of Triggering Receptor Expressed on Myeloid Cells 1 in Murine Lungs

Li Peng
Yong Zhou
Cha-Xiang Guan
ResearchOpen Access07 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Large-scale phylogenetic analyses reveal multiple gains of actinorhizal nitrogen-fixing symbioses in angiosperms associated with climate change

Hong-Lei Li
Wei Wang
Zhi-Duan Chen
ResearchOpen Access10 Sept 2015
Scientific Reports

Volume: 5, P: 1-8
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Zhan-Li Chen
Chen Xie
Shi-Mei Zhuang
ResearchOpen Access12 Jul 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-16
Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice

Jing Deng
Rui-Qi Wei
Chunmei Piao
ResearchOpen Access03 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
Doped polymer semiconductors with ultrahigh and ultralow work functions for ohmic contacts

A general strategy for producing solution-processed doped polymers with the extreme work functions that are required to make good ohmic contacts to semiconductors is demonstrated in high-performance light-emitting diodes, transistors and solar cells.

Cindy G. Tang
Mervin C. Y. Ang
Peter K. H. Ho
Research23 Nov 2016
Nature

Volume: 539, P: 536-540
GABA transporter 1 is a promising drug target for CUL4B mutation-associated epilepsy

Wei Jiang
Yan-yan Ma
Yao-qin Gong
Research21 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1580-1591
Automatic recognition system for concrete cracks with support vector machine based on crack features

Rui Wang
Rui-Qi Chen
Hai-Ying Yu
ResearchOpen Access29 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
CRISPR/Cas9-mediated VvPR4b editing decreases downy mildew resistance in grapevine (Vitis vinifera L.)

Meng-Yuan Li
Yun-Tong Jiao
Guo-Tian Liu
ResearchOpen Access01 Sept 2020
Horticulture Research

Volume: 7, P: 1-11
Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity

Rui-Qi Xu
Ling Ma
Jing Wang
ResearchOpen Access17 May 2023
Scientific Reports

Volume: 13, P: 1-13
Difference in diel mating time contributes to assortative mating between host plant-associated populations of Chilo suppressalis

Wei-Li Quan
Wen Liu
Xiao-Ping Wang
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Sunny walking counts more

Rui Zhang
Hong Chen
Hideaki Higashino
Correspondence27 Jun 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1256-1257

Search

Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control

The hornwort genome and early land plant evolution

Personality traits and brain health: a large prospective cohort study

TGF-β1 Upregulates the Expression of Triggering Receptor Expressed on Myeloid Cells 1 in Murine Lungs

Large-scale phylogenetic analyses reveal multiple gains of actinorhizal nitrogen-fixing symbioses in angiosperms associated with climate change

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice

Doped polymer semiconductors with ultrahigh and ultralow work functions for ohmic contacts

GABA transporter 1 is a promising drug target for CUL4B mutation-associated epilepsy

Automatic recognition system for concrete cracks with support vector machine based on crack features

CRISPR/Cas9-mediated VvPR4b editing decreases downy mildew resistance in grapevine (Vitis vinifera L.)

Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity

Difference in diel mating time contributes to assortative mating between host plant-associated populations of Chilo suppressalis

Sunny walking counts more

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