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Showing 1–13 of 13 results

Advanced filters: Author: Rune Linding Clear advanced filters

Retraction Note: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Thomas R. Cox
Robin M. H. Rumney
Janine T. Erler
Amendments and Corrections17 Apr 2023
Nature

Volume: 617, P: 208
Multivariate signal integration

The multivariate and integrative nature of signalling networks.

Rune Linding
Research Highlights06 May 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 391
Dynamic modularity in protein interaction networks predicts breast cancer outcome

Altered gene expression in tumors has been explored as a prognostic indicator of cancer outcome and treatment efficacy. Taylor et al. extend this approach by analyzing the coordinated expression of 'hub' proteins and their interacting partners as a means of predicting breast cancer prognosis.

Ian W Taylor
Rune Linding
Jeffrey L Wrana
Research01 Feb 2009
Nature Biotechnology

Volume: 27, P: 199-204
Global view of the RAF-MEK-ERK module and its immediate downstream effectors

Cristina C. Santini
James Longden
Rune Linding
ResearchOpen Access26 Jul 2019
Scientific Reports

Volume: 9, P: 1-11
Harnessing off-target effects

The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.

Gaye Saginc
Franziska Voellmy
Rune Linding
News & Views21 Nov 2017
Nature Chemical Biology

Volume: 13, P: 1204-1205
An atlas of substrate specificities for the human serine/threonine kinome

Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by negative selectivity

Jared L. Johnson
Tomer M. Yaron
Lewis C. Cantley
ResearchOpen Access11 Jan 2023
Nature

Volume: 613, P: 759-766
KinomeXplorer: an integrated platform for kinome biology studies

Heiko Horn
Erwin M Schoof
Rune Linding
Correspondence29 May 2014
Nature Methods

Volume: 11, P: 603-604
OpenFreezer: a reagent information management software system

Marina Olhovsky
Kelly Williton
Karen Colwill
Correspondence28 Jul 2011
Nature Methods

Volume: 8, P: 612-613
Verification of systems biology research in the age of collaborative competition

Collaborative competitions in which communities of researchers compete to solve challenges may facilitate more rigorous scrutiny of scientific results.

Pablo Meyer
Leonidas G Alexopoulos
Gustavo Stolovitzky
Comments & Opinion08 Sept 2011
Nature Biotechnology

Volume: 29, P: 811-815
Navigating cancer network attractors for tumor-specific therapy

Pau Creixell
Erwin M Schoof
Rune Linding
Reviews10 Sept 2012
Nature Biotechnology

Volume: 30, P: 842-848
RETRACTED ARTICLE: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Metastasis to the bone of certain breast cancers can be driven by the enzyme lysyl oxidase (LOX) produced by primary tumour cells.

Thomas R. Cox
Robin M. H. Rumney
Janine T. Erler
Research27 May 2015
Nature

Volume: 522, P: 106-110
Computational approaches to identify functional genetic variants in cancer genomes

International Cancer Genome Consortium members review and recommend computational approaches for identifying mutations that drive cancer progression from among the many sequence variants present in tumor genomes.

Abel Gonzalez-Perez
Ville Mustonen
Nuria Lopez-Bigas
Reviews30 Jul 2013
Nature Methods

Volume: 10, P: 723-729
Pathway and network analysis of cancer genomes

International Cancer Genome Consortium members review and recommend approaches to pathway and network analysis to uncover molecular processes that contribute to tumor biology.

Pau Creixell
Jüri Reimand
Lincoln D Stein
Reviews30 Jun 2015
Nature Methods

Volume: 12, P: 615-621