Nature Search

SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity

The antiviral protein SP140 negatively regulates Ifnb1 mRNA stability by directly repressing the expression of the immune regulator RESIST.

Kristen C. Witt
Adam Dziulko
Russell E. Vance
ResearchOpen Access11 Jun 2025
Nature

Volume: 643, P: 1372-1380
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

Eric M. Kofoed
Russell E. Vance
Research28 Aug 2011
Nature

Volume: 477, P: 592-595
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

The molecular components of inflammasomes and what they sense are poorly defined. Vance and colleagues now show the carboxy-terminal 35 amino acids of flagellin activate the inflammasome in a Naip5-dependent way.

Karla L Lightfield
Jenny Persson
Russell E Vance
Research24 Aug 2008
Nature Immunology

Volume: 9, P: 1171-1178
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1788
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1791
Venomous Vertebrates

F. E. RUSSELL
Books & Arts03 Aug 1968
Nature

Volume: 219, P: 540-541
Self-guarding of MORC3 enables virulence factor-triggered immunity

MORC3 is revealed as an essential negative regulator of the anti-viral interferon response that functions in an innate immune pathway that detects viral virulence factors.

Moritz M. Gaidt
Alyssa Morrow
Russell E. Vance
Research10 Nov 2021
Nature

Volume: 600, P: 138-142
Publisher Correction: Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

Daisy X. Ji
Livia H. Yamashiro
Russell E. Vance
Amendments and Corrections16 Apr 2020
Nature Microbiology

Volume: 5, P: 777
Self-tolerance of natural killer cells

The way in which natural killer (NK) cells acquire tolerance to self is still not fully understood. Possible mechanisms involved in NK-cell self-tolerance are discussed in detail in this Review, with an emphasis on the involvement of MHC-class-I-specific receptors.

David H. Raulet
Russell E. Vance
Reviews01 Jul 2006
Nature Reviews Immunology

Volume: 6, P: 520-531
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.

Lívia H. Yamashiro
Stephen C. Wilson
Russell E. Vance
ResearchOpen Access07 Jul 2020
Nature Communications

Volume: 11, P: 1-11
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
STING is a direct innate immune sensor of cyclic di-GMP

Dara L. Burdette
Kathryn M. Monroe
Russell E. Vance
Research25 Sept 2011
Nature

Volume: 478, P: 515-518
Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset

Kimberley J. Billingsley
Ines A. Barbosa
Sulev Koks
ResearchOpen Access22 May 2019
npj Parkinson's Disease

Volume: 5, P: 1-9
NAIP/NLRC4 inflammasome activation in MRP8⁺ cells is sufficient to cause systemic inflammatory disease

Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in neutrophils contributes to systemic inflammation.

Randilea D. Nichols
Jakob von Moltke
Russell E. Vance
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-12
Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

The maintenance of a normal intestinal microbiota is associated with gut integrity and healthy immune responses. In this issue, Janelle Ayres and her colleagues report that disruption of the gut microbiome with antibiotics, coupled with gut injury, leads to the outgrowth of a pathogenic commensal bacterium and a sepsis-like disease. Their results show that the Naip5-Nlrc4 inflammasome is crucial for sensing the pathobiont and is a key factor in triggering the disease phenotype.

Janelle S Ayres
Norver J Trinidad
Russell E Vance
Research22 Apr 2012
Nature Medicine

Volume: 18, P: 799-806
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.

Eric M. Reiman
Joseph F. Arboleda-Velasquez
Yi Zhao
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-11
Cellular teamwork in antibacterial innate immunity

IFN-γ is a cytokine that is critical for defense against intracellular bacterial pathogens. New work provides evidence that the recognition of bacterial flagellin by the NLRC4 inflammasome in splenic dendritic cells triggers rapid release of IL-18, which leads to IFN-γ production by memory CD8⁺ T cells.

Janelle S Ayres
Russell E Vance
News & Views19 Jan 2012
Nature Immunology

Volume: 13, P: 115-117
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

Dario S Zamboni
Koichi S Kobayashi
Craig R Roy
Research29 Jan 2006
Nature Immunology

Volume: 7, P: 318-325
Inflammasomes and adaptive immune responses

Deets and Vance discuss the influence of inflammasome activation on adaptive immunity.

Katherine A. Deets
Russell E. Vance
Reviews18 Feb 2021
Nature Immunology

Volume: 22, P: 412-422
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

Induction of an eicosanoid storm is shown to be an unexpected consequence of inflammasome activation in peritoneal macrophages, leading to vascular leakage and rapid death in mice.

Jakob von Moltke
Norver J. Trinidad
Russell E. Vance
Research19 Aug 2012
Nature

Volume: 490, P: 107-111
Cholesterol in quarantine

Host cell cholesterol is often exploited by pathogens for entry and egress. Two new studies elucidate a new interferon-inducible mechanism by which cells limit plasma membrane cholesterol to promote antibacterial defense.

Eric V. Dang
Hiten D. Madhani
Russell E. Vance
News & Views08 Jun 2020
Nature Immunology

Volume: 21, P: 716-717
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

A type I interferon response mediated by IL-1Ra drives susceptibility to Mycobacterium tuberculosis infection, and neutralization of IL-1Ra provides therapeutic benefit.

Daisy X. Ji
Livia H. Yamashiro
Russell E. Vance
Research14 Oct 2019
Nature Microbiology

Volume: 4, P: 2128-2135
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
SURGICALLY INDUCED IMMUNOLOGIC ALTERATIONS IN PEDIATRIC PATIENTS

Russell W Steele
F A Burrows
Daniel J Marmer
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 265
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Jan Veldink and colleagues show that loss-of-function variants in NEK1 are associated with susceptibility to amyotrophic lateral sclerosis (ALS). In addition to finding an excess of rare loss-of-function NEK1 variants in ALS cases, they report a significant association between a specific NEK1 missense variant (p.Arg261His) and disease risk.

Kevin P Kenna
Perry T C van Doormaal
John E Landers
Research25 Jul 2016
Nature Genetics

Volume: 48, P: 1037-1042
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis

Here, Rickettsia parkeri is shown to be sensitive to type I interferons (IFN-I) and IFN-γ and to benefit from inflammasome-mediated antagonism of IFN-I, highlighting similarities between the immune responses against this obligate cytosolic bacterial pathogen and those that target viral pathogens.

Thomas P. Burke
Patrik Engström
Matthew D. Welch
Research02 Mar 2020
Nature Microbiology

Volume: 5, P: 688-696
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
X‐chromosome-wide association study for Alzheimer’s disease

Julie Le Borgne
Lissette Gomez
Céline Bellenguez
ResearchOpen Access04 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2335-2346
STING and the innate immune response to nucleic acids in the cytosol

Dara L Burdette
Russell E Vance
Reviews14 Dec 2012
Nature Immunology

Volume: 14, P: 19-26
Evidence of non-uniform crust of Ceres from Dawn’s high-resolution gravity data

High-resolution gravity data from Dawn’s second extended mission could probe the global and local structure of Ceres’s crust. The results show significant spatial and vertical variations of crustal density and porosity, associated with ice features and ice-related processes driven from the interior, and impacts.

R. S. Park
A. S. Konopliv
C. T. Russell
Research10 Aug 2020
Nature Astronomy

Volume: 4, P: 748-755
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Cell death and cell lysis are separable events during pyroptosis

Lucian DiPeso
Daisy X Ji
Jordan V Price
ResearchOpen Access13 Nov 2017
Cell Death Discovery

Volume: 3, P: 1-10
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath
John C. Earls
Yi Zhao
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
Ces3/TGH Deficiency Attenuates Steatohepatitis

Jihong Lian
Enhui Wei
Richard Lehner
ResearchOpen Access16 May 2016
Scientific Reports

Volume: 6, P: 1-13

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