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Assessment and Clinical Significance of Micrometastases in Lymph Nodes of Head and Neck Cancer Patients Detected by E48 (Ly-6D) Quantitative Reverse Transcription-Polymerase Chain Reaction

Eline J C Nieuwenhuis
C René Leemans
Ruud H Brakenhoff
Research01 Aug 2003
Laboratory Investigation

Volume: 83, P: 1233-1240
Author Correction: Hallmarks of a genomically distinct subclass of head and neck cancer

Tara Muijlwijk
Irene H. Nauta
Ruud H. Brakenhoff
Amendments and CorrectionsOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1
Hallmarks of a genomically distinct subclass of head and neck cancer

HPV-negative head and neck squamous cell carcinomas (HNSCCs) are generally characterized by many copy number alterations (CNAs) and mutations. Here, the authors characterize a subgroup of HPV-negative HNSCC with no or few CNAs (CNA-quiet) by genomic profiling of 802 oral cavity squamous cell carcinomas.

Tara Muijlwijk
Irene H. Nauta
Ruud H. Brakenhoff
ResearchOpen Access20 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Publisher Correction: The molecular landscape of head and neck cancer

C. René Leemans
Peter J. F. Snijders
Ruud H. Brakenhoff
Amendments and Corrections12 Sept 2018
Nature Reviews Cancer

Volume: 18, P: 662
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients

Anne M. van Harten
Ronak Shah
Ruud H. Brakenhoff
ResearchOpen Access11 Jul 2024
Oncogenesis

Volume: 13, P: 1-10
Response to correspondence on the molecular biology of head and neck cancer

C. René Leemans
Boudewijn J. M. Braakhuis
Ruud H. Brakenhoff
Correspondence31 Mar 2011
Nature Reviews Cancer

Volume: 11, P: 382
The molecular landscape of head and neck cancer

Head and neck cancer is an unexpectedly heterogeneous disease. In this Review, Leemans, Snijders and Brakenhoff provide an update on the molecular biology of head and neck cancer, outline the role of human papillomavirus and discuss the functional role of genes involved in malignant progression to identify subgroups to personalize treatment.

C. René Leemans
Peter J. F. Snijders
Ruud H. Brakenhoff
Reviews02 Mar 2018
Nature Reviews Cancer

Volume: 18, P: 269-282
Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression

Leon J. Wils
Jos B. Poell
Elisabeth Bloemena
ResearchOpen Access02 Jan 2020
Modern Pathology

Volume: 33, P: 1033-1040
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function

Cohesion is associated with many forms of cancer. De Lange et al. show that such cohesion defects can sensitise cells to apoptosis in response to a new APC/C ubiquitin ligase inhibitor, by prolonging mitotic arrest and checkpoint activation due to cohesion fatigue.

Job de Lange
Atiq Faramarz
Rob M. F. Wolthuis
ResearchOpen Access01 Oct 2015
Nature Communications

Volume: 6, P: 1-12
Dissecting the metastatic cascade

Klaus Pantel
Ruud H. Brakenhoff
Reviews01 Jun 2004
Nature Reviews Cancer

Volume: 4, P: 448-456
Detection, clinical relevance and specific biological properties of disseminating tumour cells

Most cancer deaths are caused by metastatic spread and subsequent growth of tumour cells at distant organs. How are disseminating tumour cells relevant to the biology of early metastatic spread and how might they be used to improve cancer treatment?

Klaus Pantel
Ruud H. Brakenhoff
Burkhard Brandt
Reviews01 May 2008
Nature Reviews Cancer

Volume: 8, P: 329-340
Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest

Jojanneke Stoof
Zakaria Kalmoua
Irene V. Bijnsdorp
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
The molecular biology of head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease that often recurs, prompting the field cancerization hypothesis. This Review discusses the molecular pathology of HNSCC and how its heterogeneity can be used to classify the disease and provide a model of HNSCC development.

C. René Leemans
Boudewijn J. M. Braakhuis
Ruud H. Brakenhoff
Reviews16 Dec 2010
Nature Reviews Cancer

Volume: 11, P: 9-22
Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death

Anne M. van Harten
Marijke Buijze
Ruud H. Brakenhoff
ResearchOpen Access17 Jun 2019
Oncogenesis

Volume: 8, P: 1-16
Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition

Anne M. van Harten
D. Vicky de Boer
Ruud H. Brakenhoff
ResearchOpen Access11 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
A noninvasive genetic screening test to detect oral preneoplastic lesions

Jantine F Bremmer
Boudewijn J M Braakhuis
Ruud H Brakenhoff
Research29 Aug 2005
Laboratory Investigation

Volume: 85, P: 1481-1488
Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer

Marta Bogowicz
Arthur Jochems
Philippe Lambin
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma

A genome-wide siRNA screen on patient-derived Fanconi anemia pathway-deficient head-and-neck squamous-cell-carcinoma (HNSCC) cell lines identifies RBBP9 as a candidate therapeutic target.

Govind Pai
Khashayar Roohollahi
Josephine C. Dorsman
ResearchOpen Access13 Jan 2023
Communications Biology

Volume: 6, P: 1-12
A review of the most promising biomarkers for early diagnosis and prognosis prediction of tongue squamous cell carcinoma

Aisha A. Hussein
Tymour Forouzanfar
Marco N. Helder
ResearchOpen Access21 Aug 2018
British Journal of Cancer

Volume: 119, P: 724-736

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